Departamento de Dermatología, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
J Dermatolog Treat. 2012 Feb;23(1):57-64. doi: 10.3109/09546634.2011.631981. Epub 2011 Dec 18.
Skin photoaging is a concern for many patients today, and it is important for dermatologists to evaluate new therapeutic approaches. This 6-month open-label study evaluated the effectiveness and safety of adapalene 0.3% gel in 40 Latin American women with signs of facial photoaging. Assessments at baseline, week 12, and week 24 included clinical severity grading, measurement of transepidermal water loss, hydration, and elasticity (Cutometer MPA 850®), evaluation of general skin tone and number of wrinkles (VISIA(®) Complexion Analysis System), and ultrasonography to measure changes in skin thickness. There were significant improvements in clinical grading of wrinkles (p < 0.01) with a reduction in mean severity score of 40% in forehead wrinkles, 52% in periorbital wrinkles, and 29% in perioral wrinkles. Melanin, transepidermal water loss, and hydration were improved, as were general skin tone and the number of wrinkles (p < 0.05). Measurement of skin thickness showed a non-significant improvement in the epidermis and dermis and a significant decrease of the elastosis band (11.6% at week 12 and 15.1% at week 24). Adapalene was well tolerated overall, although three patients discontinued the study due to skin irritation in the first month. We conclude that adapalene 0.3% gel is a new safe and effective approach to photoaging.
皮肤光老化是当今许多患者关注的问题，皮肤科医生评估新的治疗方法非常重要。这项为期 6 个月的开放性标签研究评估了 40 名拉丁美洲面部光老化女性使用 0.3%阿达帕林凝胶的有效性和安全性。基线、12 周和 24 周的评估包括临床严重程度分级、经表皮水分流失测量、水分含量和弹性（Cutometer MPA 850®）、一般肤色和皱纹数量评估（VISIA®肤色分析系统）以及超声测量皮肤厚度变化。皱纹的临床分级有显著改善（p < 0.01），额部皱纹的平均严重程度评分降低了 40%，眶周皱纹降低了 52%，口周皱纹降低了 29%。黑色素、经表皮水分流失和水分含量均得到改善，肤色和皱纹数量也得到改善（p < 0.05）。皮肤厚度测量显示表皮和真皮的非显著改善，弹性带明显减少（第 12 周减少 11.6%，第 24 周减少 15.1%）。阿达帕林总体上耐受性良好，尽管有 3 名患者因第 1 个月皮肤刺激而停止研究。我们得出结论，0.3%阿达帕林凝胶是一种新的安全有效的光老化治疗方法。
