Ichibori Ryoko, Fujiwara Takashi, Tanigawa Tomoko, Kanazawa Shigeyuki, Shingaki Kenta, Torii Kosuke, Tomita Koichi, Yano Kenji, Sakai Yasuo, Hosokawa Ko
Department of Plastic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
J Cosmet Dermatol. 2014 Jun;13(2):158-63. doi: 10.1111/jocd.12081.
Twin studies, especially those involving monozygotic (MZ) twins, facilitate the analysis of factors affecting skin aging while controlling for age, gender, and genetic susceptibility. The purpose of this study was to objectively assess various features of facial skin and analyze the effects of environmental factors on these features in MZ twins. At the Osaka Twin Research Center, 67 pairs of MZ twins underwent medical interviews and photographic assessments, using the VISIA(®) Complexion Analysis System. First, the average scores of the right and left cheek skin spots, wrinkles, pores, texture, and erythema were calculated; the differences between the scores were then compared in each pair of twins. Next, using the results of medical interviews and VISIA data, we investigated the effects of environmental factors on skin aging. The data were analyzed using Pearson's correlation coefficient test and the Wilcoxon signed-rank test. The intrapair differences in facial texture scores significantly increased as the age of the twins increased (P = 0.03). Among the twin pairs who provided answers to the questions regarding history differences in medical interviews, the twins who smoked or did not use skin protection showed significantly higher facial texture or wrinkle scores compared with the twins not exposed to cigarettes or protectants (P = 0.04 and 0.03, respectively). The study demonstrated that skin aging among Japanese MZ twins, especially in terms of facial texture, was significantly influenced by environmental factors. In addition, smoking and skin protectant use were important environmental factors influencing skin aging.
双胞胎研究，尤其是那些涉及同卵双胞胎的研究，有助于在控制年龄、性别和遗传易感性的同时分析影响皮肤衰老的因素。本研究的目的是客观评估面部皮肤的各种特征，并分析环境因素对同卵双胞胎这些特征的影响。在大阪双胞胎研究中心，67对同卵双胞胎接受了医学访谈，并使用VISIA（®）肤色分析系统进行了摄影评估。首先，计算左右脸颊皮肤斑点、皱纹、毛孔、质地和红斑的平均得分；然后比较每对双胞胎得分之间的差异。接下来，利用医学访谈结果和VISIA数据，我们研究了环境因素对皮肤衰老的影响。数据采用Pearson相关系数检验和Wilcoxon符号秩检验进行分析。随着双胞胎年龄的增加，面部质地得分的配对内差异显著增加（P = 0.03）。在医学访谈中对病史差异问题提供答案的双胞胎对中，吸烟或未使用皮肤保护措施的双胞胎与未接触香烟或保护剂的双胞胎相比，面部质地或皱纹得分显著更高（分别为P = 0.04和0.03）。该研究表明，日本同卵双胞胎的皮肤衰老，尤其是在面部质方面，受环境因素的显著影响。此外，吸烟和使用皮肤保护剂是影响皮肤衰老的重要环境因素。
