发现史：血小板衍生生长因子。
History of discovery: platelet-derived growth factor.
机构信息
Department of Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA.
出版信息
Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2397-401. doi: 10.1161/ATVBAHA.108.179556.
Abstract
A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the different challenges we faced 3 decades ago in this undertaking and describes how our path was influenced by our focus on a disease process and by the evolving general understanding of the molecular effectors of cell proliferation.
摘要
在研究动脉粥样硬化病变形成的细胞和分子机制时，发现并鉴定了一种由激活的血小板释放的促生长活性物质，即血小板衍生生长因子。本文回顾了我们在 30 年前这项研究中所面临的不同挑战，并阐述了我们专注于疾病过程以及对细胞增殖分子效应器的不断深入的普遍认识是如何影响我们的研究方向的。
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