Tennant M, McGeachie J K
Department of Anatomy and Human Biology, University of Western Australia, Perth.
Aust N Z J Surg. 1991 Jul;61(7):482-8. doi: 10.1111/j.1445-2197.1991.tb00273.x.
A number of locally acting growth factors are now widely understood to be important in the regulation of cellular activity. Platelet-derived growth factor (PDGF) is one of the best known and is an important mitogenic stimulant of vascular tissues. PDGF is stored primarily by platelets but other cells, including endothelium and smooth muscle, can act as sources. The mitogenic properties of PDGF may be influential in the pathogenesis of atherosclerosis. PDGF has access to the vascular intima and may act upon smooth muscle cells to produce proliferation, a primary feature of atherosclerosis. In this brief review we examine the structure, function and influences of PDGF with special emphasis on its potential role in the pathogenesis of atherosclerosis.
现在人们普遍认为，许多局部作用的生长因子在细胞活性调节中起着重要作用。血小板衍生生长因子（PDGF）是最知名的生长因子之一，是血管组织重要的促有丝分裂刺激物。PDGF主要由血小板储存，但其他细胞，包括内皮细胞和平滑肌细胞，也可作为其来源。PDGF的促有丝分裂特性可能在动脉粥样硬化的发病机制中发挥作用。PDGF可进入血管内膜，并可能作用于平滑肌细胞以使其增殖，这是动脉粥样硬化的一个主要特征。在这篇简短的综述中，我们将研究PDGF的结构、功能及其影响，特别强调其在动脉粥样硬化发病机制中的潜在作用。
