Department of Endocrinology and Metabolism, Affiliated Huai'an Hospital, uzhou Medical College, Huai'an, China.
Clinics (Sao Paulo). 2011;66(10):1677-80. doi: 10.1590/s1807-59322011001000003.
To determine whether there is an association between serum ischemia-modified albumin and the risk factor profile in type 2 diabetic patients with peripheral arterial disease and to identify the risk markers for peripheral arterial disease.
Participants included 290 patients (35.2% women) with type 2 diabetes. The ankle-brachial pressure index was measured using a standard protocol, and peripheral arterial disease was defined as an ankle-brachial index <0.90 or >1.3. The basal ischemia-modified albumin levels and clinical parameters were measured and analyzed. The risk factors for peripheral arterial disease were examined by multiple logistic analyses.
Age, systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, urine albumin, homocysteine, and ischemia-modified albumin were significantly higher in patients with peripheral arterial disease than in disease-free patients (p<0.05), while ankle-brachial index was lower in the former group (p<0.05). Ischemia-modified albumin was positively associated with HbA1c and homocysteine levels (r = 0.220, p = 0.030; r = 0.446, p = 0.044, respectively), while no correlation was found with ankle-brachial index. Multiple logistic analyses indicated that HbA1c, systolic blood pressure, homocysteine and ischemia-modified albumin were independent risk factors for peripheral arterial disease in the diabetic subjects.
The baseline ischemia-modified albumin levels were significantly higher and positively associated with HbA1c and homocysteine levels in type 2 diabetic patients with peripheral arterial disease. Ischemia-modified albumin was a risk marker for peripheral arterial disease. Taken together, these results might be helpful for monitoring diabetic peripheral arterial disease.
确定血清缺血修饰白蛋白（ischemia-modified albumin，IMA）与伴有外周动脉疾病（peripheral arterial disease，PAD）的 2 型糖尿病患者的危险因素谱之间是否存在关联，并确定 PAD 的风险标志物。
纳入 290 例（35.2%为女性）2 型糖尿病患者。采用标准方案测量踝肱指数（ankle-brachial pressure index，ABI），ABI<0.90 或>1.3 定义为 PAD。测量并分析基础 IMA 水平和临床参数。采用多因素逻辑回归分析检查 PAD 的危险因素。
与无 PAD 患者相比，有 PAD 的患者年龄、收缩压、总胆固醇、低密度脂蛋白胆固醇、尿白蛋白、同型半胱氨酸和 IMA 水平显著升高（p<0.05），ABI 则显著降低（p<0.05）。IMA 与 HbA1c 和同型半胱氨酸水平呈正相关（r = 0.220，p = 0.030；r = 0.446，p = 0.044），与 ABI 无相关性。多因素逻辑回归分析表明，HbA1c、收缩压、同型半胱氨酸和 IMA 是糖尿病患者 PAD 的独立危险因素。
患有 PAD 的 2 型糖尿病患者的基础 IMA 水平显著升高，且与 HbA1c 和同型半胱氨酸水平呈正相关。IMA 是 PAD 的风险标志物。这些结果可能有助于监测糖尿病性 PAD。
