D'Ávila Melo Saulo Maia, Melo Valdinaldo Aragão de, Menezes Filho Raimundo Sotero de, Santos Fábio Almeida
Universidade Federal de Sergipe, Aracaju, SE, Brazil.
Rev Assoc Med Bras (1992). 2011 Sep-Oct;57(5):509-15. doi: 10.1590/s0104-42302011000500007.
To evaluate the effects of the progressive increase in body weight on lung function by oxygen peripheral saturation, spirometry and maximal respiratory pressures in different degrees of obesity.
Cross-sectional study including 140 patients in clinical and surgical evaluation for obesity treatment. The selected patients were divided into six groups of body mass index (BMI), including a control group of non-obese and a subdivision for the morbidly obese into three subgroups.
Significant differences were demonstrated between the groups regarding oxygen peripheral saturation (SpO2) (p < 0.001), forced vital capacity (FVC) (p < 0.002, p < 0.02) and forced expiratory volume in one second (FEV1) (p < 0.001, p < 0.03) in relative and absolute values, respectively. Group VI (BMI > 50.9 kg/m²) showed significant differences (SpO2, FVC and FEV1) when compared with the other groups (except group V) and group V (BMI > 45 to 49.9 kg/m²) with the group control. The other variables (FEV1/FVC ratio, forced expiratory flow 25-75 [FEF25-75] and maximal respiratory pressure) did not show any statistical differences.
Lung function is influenced by the progressive increase in BMI, with changes in lung function better demonstrated when BMI > 45 kg/m²; these changes are more evident when BMI > 50.9 kg/m².
通过外周血氧饱和度、肺量计以及不同程度肥胖患者的最大呼吸压力，评估体重逐渐增加对肺功能的影响。
横断面研究，纳入140例接受肥胖治疗临床及手术评估的患者。将所选患者按照体重指数（BMI）分为六组，包括非肥胖对照组以及将病态肥胖患者细分为三个亚组。
各组在外周血氧饱和度（SpO2）（p < 0.001）、用力肺活量（FVC）（p < 0.002，p < 0.02）和一秒用力呼气容积（FEV1）（p < 0.001，p < 0.03）的相对值和绝对值方面均显示出显著差异。与其他组（除V组外）相比，VI组（BMI > 50.9 kg/m²）以及V组（BMI > 45至49.9 kg/m²）与对照组相比，均显示出显著差异（SpO2、FVC和FEV1）。其他变量（FEV1/FVC比值、25%-75%用力呼气流量[FEF25-75]和最大呼吸压力）未显示任何统计学差异。
肺功能受BMI逐渐增加的影响，当BMI > 45 kg/m²时，肺功能变化表现更明显；当BMI > 50.9 kg/m²时，这些变化更为显著。
