Francisco C O, Catai A M, Moura-Tonello S C G, Lopes S L B, Benze B G, Del Vale A M, Leal A M O
Departamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, SP, Brasil.
Departamento de Medicina, Universidade Federal de São Carlos, São Carlos, SP, Brasil.
Braz J Med Biol Res. 2014 May;47(5):426-31. doi: 10.1590/1414-431x20143370. Epub 2014 May 2.
The objective of this study was to evaluate cardiorespiratory fitness and pulmonary function and the relationship with metabolic variables and C-reactive protein (CRP) plasma levels in individuals with diabetes mellitus (DM). Nineteen men with diabetes and 19 age- and gender-matched control subjects were studied. All individuals were given incremental cardiopulmonary exercise and pulmonary function tests. In the exercise test, maximal workload (158.3 ± 22.3 vs 135.1 ± 25.2, P=0.005), peak heart rate (HRpeak: 149 ± 12 vs 139 ± 10, P=0.009), peak oxygen uptake (VO2peak: 24.2 ± 3.2 vs 18.9 ± 2.8, P<0.001), and anaerobic threshold (VO2VT: 14.1 ± 3.4 vs 12.2 ± 2.2, P=0.04) were significantly lower in individuals with diabetes than in control subjects. Pulmonary function test parameters, blood pressure, lipid profile (triglycerides, HDL, LDL, and total cholesterol), and CRP plasma levels were not different in control subjects and individuals with DM. No correlations were observed between hemoglobin A1C (HbA1c), CRP and pulmonary function test and cardiopulmonary exercise test performance. In conclusion, the results demonstrate that nonsmoking individuals with DM have decreased cardiorespiratory fitness that is not correlated with resting pulmonary function parameters, HbA1c, and CRP plasma levels.
本研究的目的是评估糖尿病（DM）患者的心肺适能和肺功能，以及它们与代谢变量和血浆C反应蛋白（CRP）水平之间的关系。对19名患有糖尿病的男性和19名年龄及性别匹配的对照受试者进行了研究。所有个体均接受了递增式心肺运动和肺功能测试。在运动测试中，糖尿病患者的最大工作量（158.3±22.3对135.1±25.2，P=0.005）、心率峰值（HRpeak：149±12对139±10，P=0.009）、摄氧量峰值（VO2peak：24.2±3.2对18.9±2.8，P<0.001）和无氧阈值（VO2VT：14.1±3.4对12.2±2.2，P=0.04）均显著低于对照受试者。对照受试者和糖尿病患者的肺功能测试参数、血压、血脂谱（甘油三酯、高密度脂蛋白、低密度脂蛋白和总胆固醇）以及血浆CRP水平并无差异。未观察到糖化血红蛋白（HbA1c）、CRP与肺功能测试及心肺运动测试表现之间存在相关性。总之，结果表明，不吸烟的糖尿病患者心肺适能下降，且与静息肺功能参数、HbA1c及血浆CRP水平无关。
