Nocera Joe, Buford Thomas W, Manini Todd M, Naugle Kelly, Leeuwenburgh Christiaan, Pahor Marco, Perri Michael G, Anton Stephen D
Department of Veterans Affairs, Rehabilitation Research and Development, Brain Rehabilitation Research Center Malcom Randall VA Medical Center, Gainesville, FL 32608, USA.
J Aging Res. 2011;2011:392510. doi: 10.4061/2011/392510. Epub 2011 Oct 16.
A primary focus of longevity research is to identify prognostic risk factors that can be mediated by early treatment efforts. To date, much of this work has focused on understanding the biological processes that may contribute to aging process and age-related disease conditions. Although such processes are undoubtedly important, no current biological intervention aimed at increasing health and lifespan exists. Interestingly, a close relationship between mobility performance and the aging process has been documented in older adults. For example, recent studies have identified functional status, as assessed by walking speed, as a strong predictor of major health outcomes, including mortality, in older adults. This paper aims to describe the relationship between the comorbidities related to decreased health and lifespan and mobility function in obese, older adults. Concurrently, lifestyle interventions, including diet and exercise, are described as a means to improve mobility function and thereby limit the functional limitations associated with increased mortality.
长寿研究的一个主要重点是确定可通过早期治疗措施加以调节的预后风险因素。迄今为止，这项工作大多集中在了解可能导致衰老过程和与年龄相关疾病状况的生物学过程。尽管这些过程无疑很重要，但目前尚无旨在增进健康和延长寿命的生物学干预措施。有趣的是，在老年人中，运动能力与衰老过程之间的密切关系已有文献记载。例如，最近的研究已确定，通过步行速度评估的功能状态是老年人主要健康结局（包括死亡率）的有力预测指标。本文旨在描述肥胖老年人中与健康和寿命下降相关的合并症与运动功能之间的关系。同时，饮食和运动等生活方式干预措施被描述为改善运动功能从而限制与死亡率增加相关的功能限制的一种手段。
