Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel.
Expert Rev Neurother. 2011 Nov;11(11):1609-17. doi: 10.1586/ern.11.152.
Diabetes and prediabetic states have consistently been shown to be risk factors for cognitive decline, mild cognitive impairment and dementia. The importance of these findings is that diabetes and diabetes-related factors are modifiable, potentially permitting interventions aimed at postponing or preventing dementia. However, diabetes control cannot yet be implemented universally in diabetic subjects as a strategy for dementia prevention since the mechanisms by which diabetes impairs brain function and cognition are not fully understood. It is not clear which of the diabetes-related factors is crucial to this relationship. In addition, strict diabetic control has been demonstrated to carry risk for certain diabetic populations. The aim of the current article is to discuss current understanding of the relationships of diabetes and some of its characteristics with dementia, and suggest future questions to be answered.
糖尿病和糖尿病前期状态一直被证明是认知能力下降、轻度认知障碍和痴呆的危险因素。这些发现的重要性在于，糖尿病和与糖尿病相关的因素是可以改变的，有可能通过干预来延缓或预防痴呆。然而，由于糖尿病损害大脑功能和认知的机制尚未完全了解，因此不能将糖尿病控制作为预防痴呆的策略在糖尿病患者中普遍实施。目前尚不清楚与糖尿病相关的因素中哪些对这种关系至关重要。此外，严格的糖尿病控制已被证明对某些糖尿病患者群体存在风险。本文的目的是讨论目前对糖尿病及其某些特征与痴呆的关系的理解，并提出有待回答的未来问题。
