Neopetrosiquinones A 和 B，从深海海绵 Neopetrosia cf. proxima 中分离得到的倍半萜苯醌。
Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima.
机构信息
Harbor Branch Oceanographic Institute at Florida Atlantic University, Marine Biomedical and Biotechnology Research Program, Fort Pierce, FL 34946, United States.
出版信息
Bioorg Med Chem. 2011 Nov 15;19(22):6599-603. doi: 10.1016/j.bmc.2011.09.026. Epub 2011 Sep 21.
Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC(50) values of 3.7 and 9.8 μM, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC(50) values of 6.1 and 13.8 μM, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC(50) value of 6.1 μM. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone.
从 Petrosiidae 科深海海绵中分离得到两个新的海洋衍生倍半萜苯醌，分别命名为 neopetrosiquinones A（1）和 B（2）。根据其光谱数据阐明了结构。化合物 1 和 2 对 DLD-1 人结直肠腺癌细胞系的体外增殖具有抑制作用，IC（50）值分别为 3.7 和 9.8 μM，对 PANC-1 人胰腺癌细胞系的 IC（50）值分别为 6.1 和 13.8 μM。Neopetrosiquinone A（1）对 AsPC-1 人胰腺癌细胞系的体外增殖也具有抑制作用，IC（50）值为 6.1 μM。这些化合物在结构上与 alisiaquinone A、cyclozonarone 和 xestoquinone 有关。
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