College of Life Science, Shandong University, Jinan, China.
Arch Pharm Res. 2009 Nov;32(11):1581-4. doi: 10.1007/s12272-009-2110-4.
A new kalihinol diterpene, 10-epi-kalihinol X (1), together with two known related diterpenes (2 and 3), and two sesquiterpenes (4 and 5) were isolated from the Hainan sponge Acanthella sp. The structure of the new compound was elucidated on the basis of the detailed analysis of its spectroscopic data and by comparison of its NMR data with those of structurally related compounds. Compounds 1 and 3-5 exhibited in vitro moderate cytotoxicities against human lung adenocarcinoma cell line A549, with IC50 values of 9.30, 3.17, 2.44, and 1.98 microg/mL, respectively.
从海南海绵 Acanthella sp. 中分离得到一种新的卡里醇二萜，10-表-卡里醇 X（1），以及两种已知的相关二萜（2 和 3）和两种倍半萜（4 和 5）。根据其光谱数据的详细分析，并通过与结构相关化合物的 NMR 数据进行比较，确定了新化合物的结构。化合物 1 和 3-5 对人肺腺癌细胞系 A549 表现出体外中等的细胞毒性，IC50 值分别为 9.30、3.17、2.44 和 1.98 μg/mL。
