miR-590-5p、miR-219-5p、miR-15b 和 miR-628-5p 在急性髓系白血病中通常受 IL-3、GM-CSF 和 G-CSF 的共同调控。
miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia.
机构信息
Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA.
出版信息
Leuk Res. 2012 Mar;36(3):334-41. doi: 10.1016/j.leukres.2011.09.027. Epub 2011 Oct 19.
Abstract
Aberrations in IL-3, GM-CSF and G-CSF induced signaling are frequently reported in acute myeloid leukemia (AML). Herein, we utilized a unique human myeloid leukemic cell line, AML-193, which responds to all three cytokines to analyze the regulation at microRNA level. Using real-time PCR-based miRNA expression profiling, we investigated miRNA signatures regulated by IL-3, GM-CSF and G-CSF for n=704 miRNAs. We discovered that in addition to regulating specific miRNAs, these cytokines also regulate common set of miRNAs, which includes miR-590-5p, miR-219-5p, miR-15b and miR-628-5p. Taken together, we have identified novel candidate miRNAs that may be instructive during leukemic and normal hematopoiesis.
摘要
白细胞介素-3、粒细胞-巨噬细胞集落刺激因子和粒细胞集落刺激因子诱导信号的异常在急性髓系白血病（AML）中经常被报道。在此，我们利用一种独特的人髓系白血病细胞系 AML-193，该细胞系对这三种细胞因子均有反应，来分析在 miRNA 水平的调控。通过基于实时 PCR 的 miRNA 表达谱分析，我们调查了由 IL-3、GM-CSF 和 G-CSF 调控的 n=704 个 miRNA 的 miRNA 特征。我们发现，除了调控特定的 miRNA 外，这些细胞因子还调控共同的 miRNA 集，其中包括 miR-590-5p、miR-219-5p、miR-15b 和 miR-628-5p。总之，我们已经确定了在白血病和正常造血过程中可能具有指导意义的新候选 miRNA。
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