大肠杆菌 O19ab 的 O 抗原的结构和基因簇。
Structure and gene cluster of the O-antigen of Escherichia coli O19ab.
机构信息
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation.
出版信息
Carbohydr Res. 2011 Dec 13;346(17):2812-5. doi: 10.1016/j.carres.2011.09.013. Epub 2011 Sep 24.
The O-polysaccharide (O-antigen) of Escherichia coli O19ab was studied by sugar analysis along with 1D and 2D (1)H and (13)C NMR spectroscopy. The following structure of the linear pentasaccharide repeating unit was established: [See formula in text] where the degree of O-acetylation of GlcNAc is ∼33%. The O-antigen gene cluster of E. coli O19ab was sequenced. The gene functions were tentatively assigned by comparison with sequences in the available databases and found to be in full agreement with the E. coli O19ab-antigen structure.
采用糖分析并结合一维和二维（1）H 和（13）C NMR 光谱法研究了大肠杆菌 O19ab 的 O-多糖（O-抗原）。建立了线性五糖重复单元的以下结构：[见文中公式]，其中 GlcNAc 的 O-乙酰化程度约为 33%。测序了大肠杆菌 O19ab 的 O-抗原基因簇。通过与现有数据库中的序列比较，推测了基因的功能，并与大肠杆菌 O19ab-抗原结构完全一致。
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