The Cancer Hospital of the University of Chinese Academy of Sciences, Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang, China.
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, Hunan, P. R. China.
ACS Appl Mater Interfaces. 2021 Mar 3;13(8):9542-9560. doi: 10.1021/acsami.0c19562. Epub 2021 Feb 17.
In the past decades, various nanomaterials with unique properties have been explored for bioapplications. Meanwhile, aptamers, generated from the systematic evolution of ligands by exponential enrichment technology, are becoming an indispensable element in the design of functional nanomaterials because of their small size, high stability, and convenient modification, especially endowing nanomaterials with recognition capability to specific targets. Therefore, the incorporation of aptamers into nanomaterials offers an unprecedented opportunity in the research fields of diagnostics and therapeutics. Here, we focus on recent advances in aptamer-embedded nanomaterials for bioapplications. First, we briefly introduce the properties of nanomaterials that can be functionalized with aptamers. Then, the applications of aptamer-embedded nanomaterials in cellular analysis, imaging, targeted drug delivery, gene editing, and cancer diagnosis/therapy are discussed. Finally, we provide some perspectives on the challenges and opportunities that have arisen from this promising area.
在过去几十年中，人们探索了各种具有独特性质的纳米材料，以将其应用于生物领域。与此同时，适配体作为通过指数富集技术配体进化系统产生的一种物质，由于其体积小、稳定性高、修饰方便等特点，已成为功能纳米材料设计中不可或缺的元素，特别是赋予纳米材料对特定靶标的识别能力。因此，将适配体纳入纳米材料为诊断和治疗领域的研究提供了前所未有的机会。在这里，我们重点介绍了用于生物应用的嵌入适配体的纳米材料的最新进展。首先，我们简要介绍了可以与适配体功能化的纳米材料的特性。然后，讨论了嵌入适配体的纳米材料在细胞分析、成像、靶向药物输送、基因编辑和癌症诊断/治疗中的应用。最后，我们就这一充满前景的领域所带来的挑战和机遇提供了一些看法。
