Dama Madhukar Shivajirao, Rajender Singh
Division of Endocrinology, Central Drug Research Institute, Lucknow, U.P., India.
J Androl. 2012 Jul-Aug;33(4):740-4. doi: 10.2164/jandrol.111.015057. Epub 2011 Oct 20.
Several studies have described a change in semen quality over last 60 years in many regions of the world, but such studies are lacking for the Indian population. In the present study, we aimed at investigating if semen quality has changed during the last 3 decades in normal healthy Indians. We retrieved data on semen quality for Indian men without a history of infertility from published studies and analyzed it for trends in individual semen quality parameters using regression modeling. The semen parameters of 19,734 normal, healthy men from studies published over the past 33 years (from 1978 onward) were used for this purpose. Linear regression analysis weighted by sample size and controlling for age of the subjects revealed a significant decline in sperm motility and a significant increase in sperm concentration. Other semen parameters did not change significantly over this period. In conclusion, there has been a genuine decline in sperm motility and an increase in sperm concentration, which is corroborated by a recent study on Indian subjects.
多项研究描述了过去60年里世界许多地区精液质量的变化，但印度人群缺乏此类研究。在本研究中，我们旨在调查正常健康的印度男性在过去30年里精液质量是否发生了变化。我们从已发表的研究中检索了无不孕史的印度男性的精液质量数据，并使用回归模型分析了各个精液质量参数的趋势。为此，我们使用了过去33年（从1978年起）发表的研究中19734名正常、健康男性的精液参数。按样本量加权并控制受试者年龄的线性回归分析显示，精子活力显著下降，精子浓度显著增加。在此期间，其他精液参数没有显著变化。总之，精子活力确实下降，精子浓度增加，这一点得到了最近一项针对印度受试者的研究的证实。
