Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain.
J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):3-10. doi: 10.1093/gerona/glr167. Epub 2011 Oct 20.
We have investigated whether the quality of dietary fat and supplementation with coenzyme Q(10) (CoQ) modifies expression of genes related with inflammatory response and endoplasmic reticulum stress in elderly persons. Twenty participants received three diets for 4 weeks each: Mediterranean diet + CoQ (Med + CoQ), Mediterranean diet (Med), and saturated fatty acid-rich diet (SFA). After 12-hour fast, volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet. Med + CoQ diet produced a lower postprandial decrease p65 and IKK-b gene expression compared with the other diets. Our results support the anti-inflammatory effect of Med diet and that exogenous CoQ supplementation in synergy with a Med diet modulates the inflammatory response and endoplasmic reticulum stress.
我们研究了膳食脂肪的质量以及辅酶 Q(10) (CoQ) 的补充是否会改变与老年人炎症反应和内质网应激相关的基因表达。20 名参与者接受了三种饮食方案，每种方案持续四周：地中海饮食+CoQ（Med+CoQ）、地中海饮食（Med）和富含饱和脂肪酸的饮食（SFA）。禁食 12 小时后，志愿者们食用了与每种饮食中摄入的脂肪组成相似的早餐。Med 和 Med+CoQ 饮食可降低空腹钙网织蛋白、IL-1b 和 JNK-1 基因表达；降低餐后 p65、IKK-b、MMP-9、IL-1b、JNK-1、sXBP-1 和 BiP/Grp78 基因表达；并增加餐后 IkB-a 基因表达与 SFA 饮食相比。Med+CoQ 饮食与其他饮食相比，可降低餐后 p65 和 IKK-b 基因表达的下降。我们的研究结果支持 Med 饮食的抗炎作用，以及外源性 CoQ 补充与 Med 饮食协同作用可调节炎症反应和内质网应激。
