Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Am J Respir Crit Care Med. 2012 Jan 15;185(2):124-32. doi: 10.1164/rccm.201108-1502CI. Epub 2011 Oct 20.
Vitamin D deficiency and asthma are common conditions that share risk factors such as African American ethnicity, inner-city residence, and obesity. This review provides a critical examination of current experimental and epidemiologic evidence of a causal association between vitamin D status and asthma or asthma morbidity, including potential protective mechanisms such as antiviral effects and enhanced steroid responsiveness. Because most published epidemiologic studies of vitamin D and asthma or asthma morbidity are observational, a recommendation for or against vitamin D supplementation as preventive or secondary treatment for asthma is not advisable and must await results of ongoing clinical trials. Should these trials confirm a beneficial effect of vitamin D, others will be needed to assess the role of vitamin D supplementation to prevent or treat asthma in different groups such as infants, children of school age, and ethnic minorities.
维生素 D 缺乏症和哮喘是常见的疾病，它们具有共同的风险因素，如非裔美国人种族、城市内居住和肥胖。本综述批判性地检查了目前关于维生素 D 状况与哮喘或哮喘发病率之间因果关系的实验和流行病学证据，包括抗病毒作用和增强类固醇反应性等潜在保护机制。由于大多数已发表的关于维生素 D 与哮喘或哮喘发病率的流行病学研究都是观察性的，因此不建议推荐或反对将维生素 D 补充剂作为预防或治疗哮喘的手段，必须等待正在进行的临床试验结果。如果这些试验证实维生素 D 具有有益作用，那么还需要进行其他试验来评估维生素 D 补充剂在不同人群（如婴儿、学龄儿童和少数民族）中预防或治疗哮喘的作用。
