Tedeschi G, Sasso E, Marshall R W, Bonavita V
Istituto di Scienze Neurologiche, I Facoltà di Medicina, Università di Napoli.
Ital J Neurol Sci. 1990 Jun;11(3):259-63. doi: 10.1007/BF02333855.
A single blind placebo-controlled study has been performed in order to investigate objectively the acute tremorolytic effect of oral L-Dopa in ten parkinsonians chronically treated with L-Dopa. Finger tremor was assessed by means of a computerized accelerometer method, at rest and during maintenance of a fixed posture. Both resting and postural tremor were significantly influenced by L-Dopa. An "acute test" with oral L-Dopa, especially when different tremor components are investigated, may be useful for identifying objectively parkinsonians whose tremor does not respond to drug therapy or shows a deterioration of drug-responsiveness.
