附属基因组对细菌病原体进化的影响。
The influence of the accessory genome on bacterial pathogen evolution.
作者信息
Jackson Robert W, Vinatzer Boris, Arnold Dawn L, Dorus Steve, Murillo Jesús
机构信息
School of Biological Sciences; University of Reading; Whiteknights; Reading, UK.
出版信息
Mob Genet Elements. 2011 May;1(1):55-65. doi: 10.4161/mge.1.1.16432.
Abstract
Bacterial pathogens exhibit significant variation in their genomic content of virulence factors. This reflects the abundance of strategies pathogens evolved to infect host organisms by suppressing host immunity. Molecular arms-races have been a strong driving force for the evolution of pathogenicity, with pathogens often encoding overlapping or redundant functions, such as type III protein secretion effectors and hosts encoding ever more sophisticated immune systems. The pathogens' frequent exposure to other microbes, either in their host or in the environment, provides opportunities for the acquisition or interchange of mobile genetic elements. These DNA elements accessorize the core genome and can play major roles in shaping genome structure and altering the complement of virulence factors. Here, we review the different mobile genetic elements focusing on the more recent discoveries and highlighting their role in shaping bacterial pathogen evolution.
摘要
细菌病原体在其毒力因子的基因组内容上表现出显著差异。这反映了病原体通过抑制宿主免疫来感染宿主生物体所进化出的丰富策略。分子军备竞赛一直是致病性进化的强大驱动力，病原体常常编码重叠或冗余功能，如III型蛋白分泌效应器，而宿主则编码越来越复杂的免疫系统。病原体在其宿主或环境中频繁接触其他微生物，为获取或交换移动遗传元件提供了机会。这些DNA元件修饰核心基因组，并可在塑造基因组结构和改变毒力因子组成方面发挥主要作用。在这里，我们回顾不同的移动遗传元件，重点关注最新发现并突出它们在塑造细菌病原体进化中的作用。
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