Bennish M L, Salam M A, Haider R, Barza M
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
J Infect Dis. 1990 Sep;162(3):711-6. doi: 10.1093/infdis/162.3.711.
Ciprofloxacin, 500 mg every 12 h, was compared with ampicillin, 500 mg every 6 h, both given for 5 days, in the treatment of 121 adult males hospitalized with severe shigellosis. Treatment was randomized and double-blinded. At the completion of treatment, there was resolution or marked improvement in symptoms in 57 (95%) of 60 ciprofloxacin-treated patients, 23 (88%) of 26 ampicillin-treated patients infected with an ampicillin-susceptible strain of Shigella, and 15 (43%) of 35 ampicillin-treated patients infected with an ampicillin-resistant strain of Shigella (ampicillin-R group) (P less than .01, ciprofloxacin or ampicillin groups vs. ampicillin-R group). Bacteriologic failure was less common (P less than .025) in the ciprofloxacin group (0/60) than in the ampicillin (3/26, 12%) or ampicillin-R groups (5/35, 14%). Ciprofloxacin-treated patients had a mean of 29 stools during the study, compared with 46 for ampicillin-treated patients (P = .004). Thus ciprofloxacin seems to be an effective, and perhaps superior, alternative to ampicillin in treating patients with shigellosis.
对121名因严重志贺氏菌病住院的成年男性进行治疗，将每12小时服用500毫克环丙沙星与每6小时服用500毫克氨苄西林进行比较，两种药物均服用5天。治疗采用随机双盲法。治疗结束时，60名接受环丙沙星治疗的患者中有57名（95%）症状缓解或明显改善，26名感染对氨苄西林敏感志贺氏菌菌株且接受氨苄西林治疗的患者中有23名（88%）症状缓解或明显改善，35名感染对氨苄西林耐药志贺氏菌菌株且接受氨苄西林治疗的患者（氨苄西林耐药组）中有15名（43%）症状缓解或明显改善（环丙沙星组或氨苄西林组与氨苄西林耐药组相比，P<0.01）。环丙沙星组的细菌学治疗失败情况（0/60）比氨苄西林组（3/26，12%）或氨苄西林耐药组（5/35，14%）少见（P<0.025）。在研究期间，接受环丙沙星治疗的患者平均排便29次，而接受氨苄西林治疗的患者平均排便46次（P = 0.004）。因此，在治疗志贺氏菌病患者时，环丙沙星似乎是一种有效的、或许更优的氨苄西林替代药物。
