Department of Dermatology, St. Luke's-Roosevelt Hospital and Beth Israel Medical Centers, New York, NY 10025, USA.
Pediatr Allergy Immunol. 2012 Feb;23(1):50-8. doi: 10.1111/j.1399-3038.2011.01224.x. Epub 2011 Oct 21.
Wild-type varicella zoster infection (WTVZV) up to 8 yr of age has been shown to protect against atopic dermatitis (AD) and asthma. We sought to determine whether WTVZV in childhood protects against atopic disorders, allergic sensitization or decreases serum Immunoglobulin E (IgE) levels.
We conducted a retrospective, practice-based study of outpatient pediatric practices in NY. One hundred children with WTVZV up to 8 yr of age and 323 children who received varicella vaccine (VV) were randomly selected.
WTVZV up to 8 yr of age is associated with decreased odds of subsequent asthma (exact logistic regression; OR = 0.12, 95% CI = 0.03-0.57, p = 0.003), allergic rhinoconjunctivitis (OR = 0.16, 95% CI = 0.05-0.49, p = 0.0003), and AD (OR = 0.57, 95% CI = 0.33-0.96, p = 0.02), but not food allergies (p = 0.78); decreased total serum IgE levels [mixed linear model, LSM (95% CI): 129.09 (33.22-501.63) vs. 334.21 (102.38-1091.04) IU/ml; p = 0.02] remained significant at all time intervals after WTVZV (<5, 5-10, and >10) compared with VV (p = 0.003-0.03). WTVZV was associated with decreased allergic sensitization (logistic regression, OR = 0.11, 95% CI = 0.03-0.38, p = 0.0004). WTVZV is also associated with persistently decreased numbers of peripheral blood lymphocytes (p < 0.0001) for up to 12 yr (p = 0.0003-0.047), monocytes (p = 0.002) for up to 16 yr (p < 0.001) and basophils at ages 4-6, 10-12, and 14-16 (p < 0.03).
WTVZV up to 8 yr of age protects against atopic disorders, which is likely mediated by suppression of IgE production and allergic sensitization, as well as altered leukocyte distributions.
野生型水痘带状疱疹病毒（WTVZV）感染在 8 岁以下儿童中可预防特应性皮炎（AD）和哮喘。我们试图确定儿童期的 WTVZV 是否可预防特应性疾病、过敏致敏或降低血清免疫球蛋白 E（IgE）水平。
我们进行了一项回顾性、基于实践的纽约儿科诊所的研究。随机选择了 100 名 8 岁以下接受 WTVZV 治疗的儿童和 323 名接受水痘疫苗（VV）治疗的儿童。
8 岁以下的 WTVZV 与后续哮喘（确切逻辑回归；OR=0.12，95%CI=0.03-0.57，p=0.003）、过敏性鼻结膜炎（OR=0.16，95%CI=0.05-0.49，p=0.0003）和 AD（OR=0.57，95%CI=0.33-0.96，p=0.02）的发生几率降低有关，但与食物过敏无关（p=0.78）；与 VV 相比，WTVZV 后所有时间间隔（WTVZV 后<5、5-10 和>10 年）的总血清 IgE 水平均降低[混合线性模型，LSM（95%CI）：129.09（33.22-501.63）与 334.21（102.38-1091.04）IU/ml；p=0.02]，差异有统计学意义（p=0.003-0.03）。WTVZV 与过敏致敏降低有关（逻辑回归，OR=0.11，95%CI=0.03-0.38，p=0.0004）。WTVZV 还与多达 12 年的外周血淋巴细胞数量持续减少（p<0.0001）（p=0.0003-0.047）、多达 16 年的单核细胞数量减少（p=0.002）（p<0.001）以及 4-6、10-12 和 14-16 岁时的嗜碱性粒细胞数量减少有关（p<0.03）。
8 岁以下的 WTVZV 可预防特应性疾病，这可能是通过抑制 IgE 产生和过敏致敏以及改变白细胞分布来介导的。
