Beatrix Children's Hospital, UMC Groningen, The Netherlands.
Br J Nutr. 2011 Dec;106(11):1740-8. doi: 10.1017/S0007114511004053. Epub 2011 Oct 4.
The objective of the present study was to assess the effect of adding specific prebiotics to standard formula feeding on the number of fever episodes in the first year of life. In the present randomised, double-blind, placebo-controlled trial in seven centres in five West European countries, 830 healthy term infants, without a first-degree family history of allergic disease, of mothers who indicated to give only formula feeding were randomised either to receive a standard non-hydrolysed cows' milk-based formula to which a mixture of specific oligosaccharides was added (prebiotics group (PG)), or to receive a similar formula without oligosaccharides (control group (CG)). A separate reference group consisted of 300 breast-fed infants. The primary outcome was the number of fever episodes prospectively documented by the parents. There was no difference in the number of fever episodes between the PG (median value 1·19; 25th-75th percentile 0·09-2·34) and CG (1·16; 25th-75th percentile 0·06-2·38). The median number of fever episodes in the separate breast-feeding reference group was 1·24 (25th-75th percentile 0·51-3·45). There was no effect of adding specific prebiotics to standard formula feeding in reducing the number of fever episodes in the present study.
本研究旨在评估在标准配方喂养中添加特定益生元对婴儿生命第一年发热次数的影响。在这项于 5 个西欧国家的 7 个中心进行的随机、双盲、安慰剂对照试验中，纳入了 830 名健康足月婴儿，这些婴儿无过敏疾病一级家族史，其母亲表示仅给予配方奶喂养，将他们随机分配至接受添加特定低聚糖的标准非水解牛乳基配方奶（益生元组（PG））或接受不含低聚糖的类似配方奶（对照组（CG））。一个单独的母乳喂养参考组包括 300 名母乳喂养的婴儿。主要结局是父母前瞻性记录的发热次数。PG 组（中位数 1.19；25%至 75%分位数 0.09-2.34）与 CG 组（1.16；25%至 75%分位数 0.06-2.38）的发热次数无差异。单独母乳喂养参考组的中位发热次数为 1.24（25%至 75%分位数 0.51-3.45）。在本研究中，添加特定益生元对标准配方喂养并无减少发热次数的作用。
