Vivatvakin Boosba, Mahayosnond Atchara, Theamboonlers Apiradee, Steenhout Philippe G, Conus Nelly J
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Asia Pac J Clin Nutr. 2010;19(4):473-80.
Development of new infant formulas aims to replicate the benefits of breast milk. One benefit of breast milk over infant formulas is greater gastrointestinal comfort. We compared indicators of gastrointestinal comfort in infants fed a whey-predominant formula containing long-chain polyunsaturated fatty acids, galacto-oligo-saccharides and fructo-oligosaccharides, and infants fed a control casein-predominant formula without additional ingredients. The single-centre, prospective, double-blind, controlled trial randomly assigned healthy, full-term infants (n=144) to receive exclusively either experimental or control formula from 30 days to 4 months of age. A group of exclusively breast-fed infants served as reference (n=80). At 1, 2, 3, and 4 months, infants' growth parameters were measured and their health assessed. Parents recorded frequency and physical characteristics of infants' stool, frequency of regurgitation, vomiting, crying and colic. At 2-months, gastric emptying (ultrasound) and intestinal transit time (H2 breath test) were measured, and stool samples collected for bacterial analysis. Compared to the control (n=69), fewer of the experimental group (n=67) had hard stools (0.7 vs 7.5%, p<0.001) and more had soft stools (90.8 vs 82.3%, p<0.05). Also compared to the control, the experimental group's stool microbiota composition (mean % bifidobacteria: 78.1 (experimental, n=17), 63.7 (control, n=16), 74.3 (breast-fed, n=20), gastric transit times (59.6 (experimental, n=53), 61.4 (control, n=62), 55.9 (breast-fed, n=67) minutes) and intestinal transit times (data not shown) were closer to that of the breast-fed group. Growth parameter values were similar for all groups. The data suggest that, in infants, the prebiotic-containing whey-based formula provides superior gastrointestinal comfort than a control formula.
新型婴儿配方奶粉的研发旨在复制母乳的益处。母乳相较于婴儿配方奶粉的一个优势在于能给胃肠道带来更大的舒适感。我们比较了喂养含长链多不饱和脂肪酸、低聚半乳糖和低聚果糖的乳清为主的配方奶粉的婴儿与喂养不含额外成分的对照酪蛋白为主的配方奶粉的婴儿的胃肠道舒适度指标。这项单中心、前瞻性、双盲、对照试验将健康足月儿（n = 144）随机分为两组，从30天至4个月龄期间分别纯喂养试验配方奶粉或对照配方奶粉。一组纯母乳喂养的婴儿作为参照组（n = 80）。在1、2、3和4个月时，测量婴儿的生长参数并评估其健康状况。家长记录婴儿粪便的频率和物理特征、反流、呕吐、哭闹和肠绞痛的频率。在2个月时，测量胃排空（超声）和肠道转运时间（氢气呼气试验），并采集粪便样本进行细菌分析。与对照组（n = 69）相比，试验组（n = 67）中出现硬便的婴儿更少（0.7% 对7.5%，p < 0.001），出现软便的婴儿更多（90.8% 对82.3%，p < 0.05）。同样与对照组相比，试验组的粪便微生物群组成（双歧杆菌平均百分比：78.1（试验组，n = 17），63.7（对照组，n = 16），74.3（母乳喂养组，n = 20））、胃转运时间（59.6（试验组，n = 53），61.4（对照组，n = 62），55.9（母乳喂养组，n = 67）分钟）和肠道转运时间（数据未显示）更接近母乳喂养组。所有组的生长参数值相似。数据表明，对于婴儿，含益生元的乳清基配方奶粉比对照配方奶粉能提供更优的胃肠道舒适度。
