van Stuijvenberg Margriet, Stam José, Grüber Christoph, Mosca Fabio, Arslanoglu Sertac, Chirico Gaetano, Braegger Christian P, Riedler Josef, Boehm Günther, Sauer Pieter J J
Department of Paediatrics, Beatrix Children's Hospital, UMC Groningen, Groningen, The Netherlands.
Department of Pediatric Pulmonology and Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
PLoS One. 2015 Jun 15;10(6):e0129927. doi: 10.1371/journal.pone.0129927. eCollection 2015.
This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.
这是一项对在西欧五个国家七个中心开展的多中心随机安慰剂对照试验的随访研究。该随机对照试验评估了在足月出生儿童（n = 1130）的婴儿期补充含有益生元混合物（中性短链和长链低聚糖以及果胶衍生酸性低聚糖）的婴儿配方奶粉的效果。在随访研究中，672名儿童（占研究人群的60%）参与：232名（56%）来自益生元组（PG），243名（58%）来自对照组（CG），197名（66%）来自非随机母乳喂养组（BG）。主要结局是父母前瞻性记录的三至五岁时发热发作的发生情况：PG组每年1.17次（四分位间距0.50 - 2.08），CG组为1.20次（0.52 - 2.57）；BG组为1.48次（0.65 - 2.60）。在健康非特应性受试者的婴儿期给予这种特定的益生元混合物并不能减少发热发作次数，因此似乎无法预防他们在三岁至五岁生日期间的感染。
