Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan.
Am J Ophthalmol. 2012 Mar;153(3):524-529.e1. doi: 10.1016/j.ajo.2011.08.021. Epub 2011 Oct 21.
To determine the incidence of a continuous cone outer segment tips (COST) line at the fovea in spectral-domain optical coherence tomographic (SD-OCT) images of normal eyes.
Prospective, interventional case series.
Forty-six right eyes of 46 normal individuals with visual acuities (VA) ≥20/20 were studied. SD-OCT images were obtained with a Cirrus HD-OCT instrument with both the standard 5-line raster and the high-definition (HD) 5-line raster scan modes. Images with signal strengths weaker than 5 (on a scale from 0 to 10) were excluded. The appearances of the COST line, photoreceptor inner segment/outer segment (IS/OS) junction, and external limiting membrane (ELM) line were determined in a masked way.
The incidence of eyes with an intact foveal COST line was about 95%, and the incidence was not significantly associated with the age, sex, refractive error, signal strength, horizontal or vertical scans, and the use of either the standard or HD scans. Fragmented COST lines appeared to be attributable to blocking artifacts caused by a hyperreflectivity at the foveal surface because the COST fragmentation had corresponding fragmentation of the ELM and IS/OS junction lines. The correlation between a fragmented COST line and the hyperreflectivity on the retinal surface was significant for the vertical HD scans (P = .011) but not for the vertical standard, horizontal standard, or horizontal HD scans.
Commercial SD-OCT instruments can detect the COST line. Fragmentations of the COST lines in normal eyes are most likely artifacts caused by a parabolic reflection of a surface hyperreflectivity of the foveal pit.
确定正常眼的光谱域光学相干断层扫描（SD-OCT）图像中黄斑区连续圆锥外节尖端（COST）线的发生率。
前瞻性、干预性病例系列研究。
研究了 46 名视力（VA）≥20/20 的正常个体的 46 只右眼。使用 Cirrus HD-OCT 仪器获得 SD-OCT 图像，同时使用标准 5 线光栅和高清（HD）5 线光栅扫描模式。排除信号强度低于 5（0-10 级）的图像。以屏蔽方式确定 COST 线、光感受器内节/外节（IS/OS）连接和外部限制膜（ELM）线的外观。
具有完整黄斑 COST 线的眼的发生率约为 95%，发生率与年龄、性别、屈光不正、信号强度、水平或垂直扫描以及使用标准或 HD 扫描均无显著相关性。碎片 COST 线似乎归因于黄斑表面的高反射性引起的阻断伪影，因为 COST 断裂与 ELM 和 IS/OS 连接线的相应断裂有关。垂直 HD 扫描时，COST 线断裂与视网膜表面高反射性之间的相关性具有统计学意义（P =.011），而垂直标准扫描、水平标准扫描或水平 HD 扫描时则无相关性。
商用 SD-OCT 仪器可检测 COST 线。正常眼中 COST 线的断裂很可能是黄斑凹表面高反射性的抛物线反射引起的伪影。
