Gu Ruiping, Deng Guohua, Jiang Yi, Jiang Chunhui, Xu Gezhi
Department of Ophthalmology, Eye and ENT Hospital and Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai Medical College, Fudan University, Shanghai, 200031, China.
Department of Ophthalmology, The Third People's Hospital of Changzhou, Changzhou, 213000, China.
BMC Ophthalmol. 2018 Aug 1;18(1):188. doi: 10.1186/s12886-018-0862-7.
Numerous studies have suggested that the integrity of the cone interdigitation zone (IZ) could be considered to be a marker of photoreceptor damage and its recovery. However, little is known about the IZ in healthy eyes. Our present study was to measure the cone IZ area by optical coherence tomography (OCT), and determine its distribution in healthy adults.
This was a cross-sectional non-interventional study. We involved a group of 158 emmetropic or low myopic (from -3D to + 0.5D) eyes in 97 healthy adult volunteers. All subjects underwent thorough ophthalmologic examinations and the posterior pole was scanned by OCT. The cone IZ area in healthy adults and its correlation with macular volume and other factors was analyzed.
The cone IZ was visible and clear in all 158 eyes, and the IZ area was successfully measured by 6 radical scans centered on the fovea. The mean IZ area was 30.22 ± 12.70 mm, and ranged from 5.91 to 57.47 mm. The IZ area exhibited a normal distribution (P = 0.635) with 95% confidence interval of 28.06-32.29 mm. The IZ area was significantly correlated with the retinal and outer nuclear layer (ONL) volumes within the macula.
The cone IZ area could be measured using a commercially available OCT system. The IZ area showed high variability among healthy adults, and this might be related to the variability in the photoreceptor distribution in healthy adults.
大量研究表明，视锥细胞指状交叉区（IZ）的完整性可被视为光感受器损伤及其恢复的标志物。然而，对于健康眼睛中的IZ了解甚少。我们目前的研究旨在通过光学相干断层扫描（OCT）测量视锥细胞IZ面积，并确定其在健康成年人中的分布。
这是一项横断面非干预性研究。我们纳入了97名健康成年志愿者的158只正视或低度近视（-3D至+0.5D）眼睛。所有受试者均接受了全面的眼科检查，并通过OCT扫描了后极部。分析了健康成年人的视锥细胞IZ面积及其与黄斑体积和其他因素的相关性。
在所有158只眼中，视锥细胞IZ均可见且清晰，通过以中央凹为中心的6次径向扫描成功测量了IZ面积。平均IZ面积为30.22±12.70平方毫米，范围为5.91至57.47平方毫米。IZ面积呈正态分布（P = 0.635），95%置信区间为28.06 - 32.29平方毫米。IZ面积与黄斑区内的视网膜和外核层（ONL）体积显著相关。
视锥细胞IZ面积可以使用市售的OCT系统进行测量。IZ面积在健康成年人中显示出高度变异性，这可能与健康成年人光感受器分布的变异性有关。
