Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Cytokine Growth Factor Rev. 2011 Aug;22(4):189-95. doi: 10.1016/j.cytogfr.2011.10.001. Epub 2011 Oct 22.
The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level of interest in how this protein is produced and exported from cells. However, the mechanism of IL-1β release has proven to be elusive. It does not follow the conventional ER-Golgi route of secretion. A literature full of disparate observations arising from numerous experimental systems, has contributed to a complicated mix of diverse proposals. Here we summarise these observations and propose that secretion of IL-1β occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1β requirement.
细胞因子白细胞介素-1β（IL-1β）是炎症反应的关键介质。它对宿主的反应和对病原体的抵抗力至关重要，但也会加剧慢性疾病和急性组织损伤期间的损害。因此，人们对这种蛋白质如何从细胞中产生和输出非常感兴趣，这并不奇怪。然而，IL-1β释放的机制一直难以捉摸。它不遵循传统的内质网-高尔基体分泌途径。文献中充满了来自众多实验系统的不同观察结果，这些结果促成了各种不同提议的复杂混合。在这里，我们总结了这些观察结果，并提出 IL-1β的分泌是一个连续的过程，取决于刺激强度和细胞外 IL-1β的需求。
