Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Clin Biochem. 2012 Jan;45(1-2):144-7. doi: 10.1016/j.clinbiochem.2011.09.022. Epub 2011 Oct 14.
We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects.
Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) 25 kg/m(2)), 100 overweight subjects (BMI 25 to 30 kg/m(2)) (n=100) and 100 obese subjects (BMI ≥ 30 kg/m(2)).
Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P<0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P<0.05).
High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity.
我们评估了肥胖指数与健康受试者 HSP-27 抗体滴度之间的关系。
共研究了 250 名受试者，包括 50 名正常体重受试者（体重指数（BMI）为 25kg/m(2)）、100 名超重受试者（BMI 为 25 至 30kg/m(2)）（n=100）和 100 名肥胖受试者（BMI≥30kg/m(2)）。
肥胖受试者的抗 HSP27 抗体水平为[0.34（0.20-0.39）吸光度单位]，明显高于超重和正常体重组（P<0.05）。超重受试者的抗 HSP27 抗体水平[0.29（0.15-0.34）吸光度单位]明显高于对照组[0.18（0.10-0.23）吸光度单位]（P<0.05）。
无明确冠心病的肥胖患者中高抗 HSP-27 抗体水平可能与肥胖相关的免疫激活状态增强有关。
