Ghayour-Mobarhan M, Taylor A, Lamb D J, Ferns G A A
Centre for Clinical Science & Measurement, School of Biomedical & Molecular Science, University of Surrey, Guildford, Surrey, UK.
Int J Obes (Lond). 2007 Jan;31(1):197-200. doi: 10.1038/sj.ijo.0803385. Epub 2006 May 16.
We have previously shown that antibody titres to several heat-shock proteins (Hsps) are elevated in dyslipidaemic patients and subjects with established vascular disease. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. Hence, we have investigated the association between indices of obesity and several Hsp antibody titres in healthy subjects. Subjects (n=170) were recruited from among employees at the University of Surrey and the Royal Surrey County Hospital, Guildford, UK. Of these subjects, 35 were obese with a body mass index (BMI)>/=30 kg/m(2) (19 male and 16 female subjects), 58 were overweight with 30>BMI>/=25 kg/m(2) (36 male and 22 female subjects) and 77 were of a normal weight with BMI<25 kg/m(2) (31 male and 46 female subjects). Overall, obese subjects had significantly higher plasma anti-Hsp-60 (P<0.001), anti-Hsp-65 (P<0.05) and anti-Hsp-70 (P<0.05) compared with overweight and normal weight subjects.
我们之前已经表明，血脂异常患者和已患血管疾病的受试者体内，针对几种热休克蛋白（Hsps）的抗体滴度会升高。众所周知，肥胖与血清炎症标志物升高有关，提示免疫激活增强的状态。因此，我们研究了健康受试者中肥胖指标与几种Hsp抗体滴度之间的关联。受试者（n = 170）从英国吉尔福德萨里大学和皇家萨里郡医院的员工中招募。在这些受试者中，35人肥胖，体重指数（BMI）≥30 kg/m²（19名男性和16名女性受试者），58人超重，30＞BMI≥25 kg/m²（36名男性和22名女性受试者），77人体重正常，BMI＜25 kg/m²（31名男性和46名女性受试者）。总体而言，与超重和体重正常的受试者相比，肥胖受试者的血浆抗Hsp - 60（P＜0.001）、抗Hsp - 65（P＜0.05）和抗Hsp - 70（P＜0.05）水平显著更高。
