Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle-upon-Tyne, NE2 4AX, UK.
Nat Rev Microbiol. 2011 Oct 24;10(1):8-12. doi: 10.1038/nrmicro2671.
The bacterial cell cycle requires the tight regulation and precise coordination of several sophisticated cellular processes. Prominent among them is the formation of the dividing wall or septum, which has to take place at the right time and place to ensure equality of the progeny and integrity of the genome. Nucleoid occlusion is a defence mechanism that prevents the chromosome from being bisected and broken by the division septum. It does so by preventing Z ring formation near the nucleoid, which also helps to determine the location of septation.
细菌细胞周期需要对几个复杂的细胞过程进行严格的调节和精确的协调。其中突出的是分裂壁或隔膜的形成，它必须在适当的时间和地点进行，以确保后代的均等和基因组的完整性。类核封闭是一种防御机制，可防止染色体被分裂隔膜一分为二和断裂。它通过防止在类核附近形成 Z 环来实现这一点，这也有助于确定隔膜的位置。
