Department of Radiology, Urmia University of Medical Sciences, Urmia, Iran.
J Ovarian Res. 2011 Oct 24;4(1):19. doi: 10.1186/1757-2215-4-19.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of childbearing age, and it seems better to consider it as an ovarian manifestation of metabolic syndrome. The aim of the current study was to evaluate early atherosclerotic findings in patients with PCOS.
We enrolled 46 women with PCOS and 45 normal control subjects who were referred to our hospital's endocrinology outpatient clinic. Carotid intima media thickness (CIMT) and flow-mediated dilatation (FMD) were performed in both cases and matched controls.
Patients with PCOS showed an increased mean CIMT (0.63 ± 0.16 mm) when compared with the control subjects (0.33 ± 0.06 mm). This difference was statistically significant (p = 0.001). The mean FMD in young patients with PCOS was 10.07 ± 1.2%, while it was 6.5 ± 2.06% in normal subjects. This difference was also statistically significant (p = 0.001).
Our findings suggest that PCOS is related with early atherosclerotic findings.
多囊卵巢综合征（PCOS）是育龄妇女中最常见的内分泌疾病，似乎可以将其视为代谢综合征的卵巢表现。本研究旨在评估多囊卵巢综合征患者的早期动脉粥样硬化发现。
我们招募了 46 名多囊卵巢综合征患者和 45 名正常对照者，他们均被转介至我们医院的内分泌科门诊。对所有病例和匹配对照者进行颈动脉内膜中层厚度（CIMT）和血流介导的扩张（FMD）检测。
与对照组（0.33 ± 0.06 mm）相比，PCOS 患者的平均 CIMT（0.63 ± 0.16 mm）更高，差异具有统计学意义（p = 0.001）。年轻的 PCOS 患者的平均 FMD 为 10.07 ± 1.2%，而正常对照者为 6.5 ± 2.06%。差异也具有统计学意义（p = 0.001）。
我们的研究结果表明，多囊卵巢综合征与早期动脉粥样硬化发现有关。
