NOD 样受体 NLRC5 对免疫途径的调节。
Regulation of immune pathways by the NOD-like receptor NLRC5.
机构信息
Department of Biochemistry, Ghent University, Ghent, Belgium.
出版信息
Immunobiology. 2012 Jan;217(1):13-6. doi: 10.1016/j.imbio.2011.08.011. Epub 2011 Sep 8.
Abstract
Members of the nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family are quickly emerging as critical regulators of innate and adaptive immune responses during microbial infection and autoimmunity. The NLR family member NLRC5 was recently proposed to function as a positive and negative regulator of antiviral immune responses. NLRC5 has also been implicated in regulation of inflammasome signaling and MHC class I transcription. Some of these functions have recently been assessed in NLRC5-deficient mice and immune cells. Here, we summarize and review the newly gained knowledge on the structure, expression profile and putative functions of NLRC5 in regulating immune responses and host defense.
摘要
核苷酸结合寡聚化结构域（NOD）样受体（NLR）家族成员在微生物感染和自身免疫过程中迅速成为先天和适应性免疫反应的关键调节因子。最近提出 NLR 家族成员 NLRC5 作为抗病毒免疫反应的正调节因子和负调节因子。NLRC5 还参与调节炎症小体信号和 MHC Ⅰ类转录。这些功能中的一些最近在 NLRC5 缺陷小鼠和免疫细胞中进行了评估。在这里，我们总结和回顾了 NLRC5 在调节免疫反应和宿主防御方面的结构、表达谱和潜在功能的新认识。
相似文献
1
Regulation of immune pathways by the NOD-like receptor NLRC5.NOD 样受体 NLRC5 对免疫途径的调节。
Immunobiology. 2012 Jan;217(1):13-6. doi: 10.1016/j.imbio.2011.08.011. Epub 2011 Sep 8.
2
Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 T Cell Function and Impaired Viral Clearance.核苷酸结合寡聚化结构域样受体NLRC5的缺陷导致CD8 T细胞功能下降和病毒清除受损。
J Virol. 2017 Aug 10;91(17). doi: 10.1128/JVI.00377-17. Print 2017 Sep 1.
3
NLRC5: a key regulator of MHC class I-dependent immune responses.NLRC5：MHC I 类依赖性免疫反应的关键调节因子。
Nat Rev Immunol. 2012 Dec;12(12):813-20. doi: 10.1038/nri3339.
4
NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens.NLRC5 调节 MHC I 类抗原呈递，以宿主防御细胞内病原体。
Cell Res. 2012 May;22(5):836-47. doi: 10.1038/cr.2012.56. Epub 2012 Apr 10.
5
Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice.NLRC5 缺陷型小鼠中 TLR 诱导的 NF-κB 信号和 I 型干扰素反应增强。
Cell Res. 2012 May;22(5):822-35. doi: 10.1038/cr.2012.53. Epub 2012 Apr 3.
6
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.NLRC5 缺乏选择性地损害了 MHC Ⅰ类依赖性细胞毒性 T 细胞对淋巴细胞的杀伤作用。
J Immunol. 2012 Apr 15;188(8):3820-8. doi: 10.4049/jimmunol.1102671. Epub 2012 Mar 12.
7
Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5.NLRC5 的新兴主要组织相容性复合体 I 相关功能。
Adv Immunol. 2017;133:89-119. doi: 10.1016/bs.ai.2016.11.003. Epub 2017 Jan 3.
8
MHC class I transactivator NLRC5 in host immunity, cancer and beyond.MHC Ⅰ类转录激活因子 NLRC5 在宿主免疫、癌症及其他方面的作用
Immunology. 2021 Mar;162(3):252-261. doi: 10.1111/imm.13235. Epub 2020 Aug 3.
9
The expanding role of NLRs in antiviral immunity.NLRs 在抗病毒免疫中的作用不断扩大。
Immunol Rev. 2013 Sep;255(1):13-24. doi: 10.1111/imr.12089.
10
NLRC5 deficiency protects against acute kidney injury in mice by mediating carcinoembryonic antigen-related cell adhesion molecule 1 signaling.NLRC5 缺乏通过调节癌胚抗原相关细胞黏附分子 1 信号转导来保护小鼠急性肾损伤。
Kidney Int. 2018 Sep;94(3):551-566. doi: 10.1016/j.kint.2018.02.031. Epub 2018 Jun 12.
引用本文的文献
1
Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress.热应激条件下，雏鸡由于硒缺乏导致的多组织损伤，以及免疫和氧化还原平衡失调。
Sci China Life Sci. 2023 Sep;66(9):2056-2069. doi: 10.1007/s11427-022-2226-1. Epub 2023 Feb 10.
2
NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).NLRC5 通过促进 E3 连接酶 CUL2（连接酶 2）介导的病毒 NS3 的自噬降解来限制登革热病毒感染。
Autophagy. 2023 Apr;19(4):1332-1347. doi: 10.1080/15548627.2022.2126614. Epub 2022 Sep 29.
3
Coronavirus Porcine Deltacoronavirus Upregulates MHC Class I Expression through RIG-I/IRF1-Mediated NLRC5 Induction.猪德尔塔冠状病毒通过 RIG-I/IRF1 介导的 NLRC5 诱导上调 MHC Ⅰ类分子的表达。
J Virol. 2022 Apr 13;96(7):e0015822. doi: 10.1128/jvi.00158-22. Epub 2022 Mar 21.
4
Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population.维生素 D 补充对缺乏人群的免疫调节作用。
Int J Mol Sci. 2021 May 10;22(9):5041. doi: 10.3390/ijms22095041.
5
NLRP12 in innate immunity and inflammation.NLRP12 在先天免疫和炎症中的作用。
Mol Aspects Med. 2020 Dec;76:100887. doi: 10.1016/j.mam.2020.100887. Epub 2020 Aug 22.
6
Role of Inflammasomes in HIV-1 and Drug Abuse Mediated Neuroinflammaging.炎症小体在 HIV-1 和药物滥用介导的神经炎症老化中的作用。
Cells. 2020 Aug 8;9(8):1857. doi: 10.3390/cells9081857.
7
NLRC5: new cancer buster?NLRC5：新的癌症克星？
Mol Biol Rep. 2020 Mar;47(3):2265-2277. doi: 10.1007/s11033-020-05253-5. Epub 2020 Jan 10.
8
NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ.NLRC5 抑制血管损伤后的新内膜形成，并与 PPARγ 直接相互作用。
Nat Commun. 2019 Jun 28;10(1):2882. doi: 10.1038/s41467-019-10784-y.
9
HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis.HIV-1 Tat 介导的小胶质细胞炎症涉及一种新型的 miRNA-34a-NLRC5-NFκB 信号通路。
Brain Behav Immun. 2019 Aug;80:227-237. doi: 10.1016/j.bbi.2019.03.011. Epub 2019 Mar 11.
10
The Obligate Intracellular Bacterium Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway.专性细胞内细菌靶向 NLRC5 调节主要组织相容性复合物 I 类途径。
Infect Immun. 2019 Feb 21;87(3). doi: 10.1128/IAI.00876-18. Print 2019 Mar.
本文引用的文献
1
Cutting edge: NLRC5-dependent activation of the inflammasome.前沿：NLRC5 依赖性的炎症小体激活。
J Immunol. 2011 Feb 1;186(3):1333-7. doi: 10.4049/jimmunol.1003111. Epub 2010 Dec 29.
2
NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections.NLRC5 缺乏并不影响病毒和细菌感染引起的细胞因子诱导。
J Immunol. 2011 Jan 15;186(2):994-1000. doi: 10.4049/jimmunol.1002094. Epub 2010 Dec 8.
3
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.NLR 家族成员 NLRC5 是 MHC Ⅰ类基因的转录调节因子。
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13794-9. doi: 10.1073/pnas.1008684107. Epub 2010 Jul 16.
4
NLRC5 limits the activation of inflammatory pathways.NLRC5 限制炎症途径的激活。
J Immunol. 2010 Aug 1;185(3):1681-91. doi: 10.4049/jimmunol.0903900. Epub 2010 Jul 7.
5
A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses.核苷酸结合结构域、富含亮氨酸重复序列家族成员 NLRC5 在抗病毒反应中的作用。
J Biol Chem. 2010 Aug 20;285(34):26223-32. doi: 10.1074/jbc.M110.109736. Epub 2010 Jun 10.
6
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.NLRC5 负调控 NF-κB 和 I 型干扰素信号通路。
Cell. 2010 Apr 30;141(3):483-96. doi: 10.1016/j.cell.2010.03.040.
7
Nlrp3: an immune sensor of cellular stress and infection.Nlrp3：细胞应激和感染的免疫传感器。
Int J Biochem Cell Biol. 2010 Jun;42(6):792-5. doi: 10.1016/j.biocel.2010.01.008. Epub 2010 Jan 13.
8
The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.核苷酸结合寡聚化结构域样受体 NLRC5 参与 IFN 依赖性抗病毒免疫反应。
J Immunol. 2010 Feb 15;184(4):1990-2000. doi: 10.4049/jimmunol.0900557. Epub 2010 Jan 8.
9
Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs.了解人类先天免疫受体的多样性：分析NLR和TLR中富含亮氨酸重复序列结构域的表面特征。
BMC Immunol. 2009 Sep 3;10:48. doi: 10.1186/1471-2172-10-48.
10
Pathogen recognition in the innate immune response.天然免疫反应中的病原体识别
Biochem J. 2009 Apr 28;420(1):1-16. doi: 10.1042/BJ20090272.
Zotero 插件