利用靶向肽标记的硫化铋纳米粒子进行乳腺癌 X 射线计算机断层成像。
X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles.
机构信息
Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Dec 16;50(51):12308-11. doi: 10.1002/anie.201104507. Epub 2011 Oct 26.
Abstract
Enhanced visualization of breast cancer using X-ray microComputed Tomography is achieved using 10nm-diameter BiS nanoparticles, modified to display a tumor homing peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260% over non-labeled nanoparticles.
摘要
利用 X 射线微计算机断层扫描增强乳腺癌的可视化效果，使用的是直径为 10nm 的 BiS 纳米粒子，经过修饰后可显示肿瘤归巢肽（LyP-1，CGNKRTRGC）。与未标记的纳米粒子相比，肿瘤内的积累增加了 260%。
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