Taylor Brandie D, Darville Toni, Tan Chun, Bavoil Patrik M, Ness Roberta B, Haggerty Catherine L
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Infect Dis Obstet Gynecol. 2011;2011:989762. doi: 10.1155/2011/989762. Epub 2011 Oct 19.
Chlamydia trachomatis polymorphic membrane proteins (Pmps) may increase genital tract inflammation and play a role in virulence. Antibody levels for PmpA, PmpD, and PmpI, measured in densitometric units, were assessed among a pilot sample of 40 C. trachomatis-infected women with mild-to-moderate clinical PID. Women who expressed antibodies to PmpA were less likely to achieve pregnancy (40.0% versus 85.7%; P = 0.042) and less likely to have a live birth (0.0% versus 80.0%; P = 0.005) compared to women who did not express antibody to PmpA. Women who expressed antibodies to PmpI were more likely to have upper genital tract infection (61.5% versus 20.0%; P = 0.026). However, seropositivity to PmpI and PmpD did not modify the risk of reproductive sequelae or inflammation. Seropositivity to chlamydial PmpA may represent a biomarker of increased risk of sequelae secondary to infection with C. trachomatis.
沙眼衣原体多态性膜蛋白（Pmps）可能会加重生殖道炎症并在毒力方面发挥作用。在40名患有轻至中度临床盆腔炎的沙眼衣原体感染女性的试点样本中，评估了以光密度单位测量的PmpA、PmpD和PmpI的抗体水平。与未表达PmpA抗体的女性相比，表达PmpA抗体的女性怀孕的可能性较小（40.0%对85.7%；P = 0.042），活产的可能性也较小（0.0%对80.0%；P = 0.005）。表达PmpI抗体的女性更有可能发生上生殖道感染（61.5%对20.0%；P = 0.026）。然而，对PmpI和PmpD的血清阳性反应并未改变生殖后遗症或炎症的风险。沙眼衣原体PmpA血清阳性反应可能代表沙眼衣原体感染后继发后遗症风险增加的生物标志物。
