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Pathogenesis of Chlamydia induced pelvic inflammatory disease.衣原体所致盆腔炎的发病机制。
Sex Transm Infect. 1999 Feb;75(1):21-4. doi: 10.1136/sti.75.1.21.
2
Persistence of chlamydial antibodies after pelvic inflammatory disease.盆腔炎后衣原体抗体的持续存在。
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Antibodies to Chlamydia trachomatis in women with infertility, pelvic inflammatory disease and ectopic pregnancy.患有不孕症、盆腔炎和宫外孕的女性体内沙眼衣原体抗体。
Eur J Obstet Gynecol Reprod Biol. 1990 May-Jun;35(2-3):199-204. doi: 10.1016/0028-2243(90)90162-t.
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Acute pelvic inflammatory disease.急性盆腔炎
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Chlamydia antibodies, chlamydia heat shock protein, and adverse sequelae after pelvic inflammatory disease: the PID Evaluation and Clinical Health (PEACH) Study.衣原体抗体、衣原体热休克蛋白与盆腔炎后的不良后遗症:盆腔炎评估与临床健康(PEACH)研究
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本文引用的文献

1
Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease.盆腔炎女性对沙眼衣原体保守表位和人60 kDa热休克蛋白的体液免疫反应。
J Infect Dis. 1998 Mar;177(3):714-9. doi: 10.1086/514218.
2
B-cell-deficient mice develop complete immune protection against genital tract infection with Chlamydia trachomatis.B细胞缺陷型小鼠对沙眼衣原体生殖道感染产生完全的免疫保护。
Immunology. 1997 Dec;92(4):422-8. doi: 10.1046/j.1365-2567.1997.00378.x.
3
Studies in knockout mice reveal that anti-chlamydial protection requires TH1 cells producing IFN-gamma: is this true for humans?对基因敲除小鼠的研究表明,抗衣原体感染的保护作用需要产生γ干扰素的TH1细胞:对人类而言也是如此吗?
Scand J Immunol. 1997 Dec;46(6):546-52. doi: 10.1046/j.1365-3083.1997.d01-167.x.
4
Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.鼠沙眼衣原体继发感染中的体液免疫和细胞免疫。
Infect Immun. 1997 Jul;65(7):2876-82. doi: 10.1128/iai.65.7.2876-2882.1997.
5
Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease.性病门诊就诊女性及确诊盆腔炎女性中衣原体热休克蛋白抗体的患病率及其相关因素
J Infect Dis. 1997 Jun;175(6):1453-8. doi: 10.1086/516479.
6
Evidence of genetic susceptibility to Chlamydia trachomatis-induced pelvic inflammatory disease in the pig-tailed macaque.猪尾猕猴对沙眼衣原体引起的盆腔炎的遗传易感性证据。
Infect Immun. 1997 Jun;65(6):2250-3. doi: 10.1128/iai.65.6.2250-2253.1997.
7
Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring.恒河猴输卵管反复感染沙眼衣原体可产生与纤维化和瘢痕形成相关的Th1样细胞因子反应。
Infect Immun. 1997 Jun;65(6):2175-82. doi: 10.1128/iai.65.6.2175-2182.1997.
8
Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease.抗衣原体热休克蛋白60抗体预示衣原体性盆腔炎风险增加。
J Infect Dis. 1997 May;175(5):1153-8. doi: 10.1086/516454.
9
Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10.对热休克蛋白60的自身免疫及白细胞介素-10的抗原特异性产生
Infect Immun. 1997 May;65(5):1669-74. doi: 10.1128/iai.65.5.1669-1674.1997.
10
Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.上皮细胞对衣原体感染作出反应而分泌促炎细胞因子,这表明上皮细胞在衣原体发病机制中起核心作用。
J Clin Invest. 1997 Jan 1;99(1):77-87. doi: 10.1172/JCI119136.

衣原体所致盆腔炎的发病机制。

Pathogenesis of Chlamydia induced pelvic inflammatory disease.

作者信息

Cohen C R, Brunham R C

机构信息

Department of Obstetrics and Gynecology, University of Washington, Seattle 98103-6460, USA.

出版信息

Sex Transm Infect. 1999 Feb;75(1):21-4. doi: 10.1136/sti.75.1.21.

DOI:10.1136/sti.75.1.21
PMID:10448337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1758172/
Abstract

Further research is necessary to elucidate the pathogenesis of chlamydial PID. It is hoped that these endeavours will eventually lead to a vaccine to prevent not only chlamydia infection, but also chlamydia associated infertility, ectopic pregnancy, and chronic pelvic pain. In the meantime we need to develop strategies to prevent primary and secondary chlamydia infection and its sequelae. Recently, Scholes et. al demonstrated that a population based approach to identify and test women at high risk for cervical C trachomatis infection effectively reduced risk of PID. Hopefully, through the use of public health measures, we can see similar decreases of chlamydia associated genital tract disease worldwide.

摘要

有必要进行进一步研究以阐明衣原体性盆腔炎的发病机制。希望这些努力最终能研发出一种疫苗,不仅可预防衣原体感染,还能预防与衣原体相关的不孕、异位妊娠和慢性盆腔疼痛。与此同时,我们需要制定策略来预防衣原体的原发和继发感染及其后遗症。最近,斯科尔斯等人证明,采用基于人群的方法来识别和检测宫颈沙眼衣原体感染高危女性,可有效降低盆腔炎风险。有望通过公共卫生措施的实施,在全球范围内看到衣原体相关生殖道疾病的类似减少。