衰老神经系统中整合睡眠驱动力和昼夜节律波动的疾病与退化。
Disease and Degeneration of Aging Neural Systems that Integrate Sleep Drive and Circadian Oscillations.
机构信息
Center for Sleep and Circadian Neurobiology, School of Medicine, University of Pennsylvania Philadelphia, PA, USA.
出版信息
Front Neurol. 2011 Oct 24;2:66. doi: 10.3389/fneur.2011.00066. eCollection 2011.
Abstract
Sleep/wake and circadian rest-activity rhythms become irregular with age. Typical outcomes include fragmented sleep during the night, advanced sleep phase syndrome and increased daytime sleepiness. These changes lead to a reduction in the quality of life due to cognitive impairments and emotional stress. More importantly, severely disrupted sleep and circadian rhythms have been associated with an increase in disease susceptibility. Additionally, many of the same brain areas affected by neurodegenerative diseases include the sleep and wake promoting systems. Any advances in our knowledge of these sleep/wake and circadian networks are necessary to target neural areas or connections for therapy. This review will discuss research that uses molecular, behavioral, genetic and anatomical methods to further our understanding of the interaction of these systems.
摘要
睡眠/觉醒和昼夜节律的休息-活动节律随着年龄的增长而变得不规律。典型的结果包括夜间睡眠碎片化、睡眠相位提前综合征和白天嗜睡增加。这些变化导致认知障碍和情绪压力导致生活质量下降。更重要的是，严重的睡眠和昼夜节律紊乱与疾病易感性增加有关。此外，许多受神经退行性疾病影响的相同大脑区域包括睡眠和觉醒促进系统。我们对这些睡眠/觉醒和昼夜节律网络的任何了解的进展都有必要针对神经区域或连接进行治疗。这篇综述将讨论使用分子、行为、遗传和解剖学方法来进一步了解这些系统相互作用的研究。
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