头孢他啶与妥布霉素在肾功能正常和受损患者中的相互作用。
Interactions of ceftazidime and tobramycin in patients with normal and impaired renal function.
作者信息
Aronoff G R, Brier R A, Sloan R S, Brier M E
机构信息
Department of Medicine, Indiana University Medical Center, Indianapolis 46202.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1139-42. doi: 10.1128/AAC.34.6.1139.
We studied the in vivo interaction of ceftazidime and tobramycin in normal volunteers and anuric patients given each drug separately or both drugs in combination. Kinetic analysis of plasma concentration data showed minor changes in the disposition of these agents when they were given concurrently. However, the resulting clearance of both tobramycin and ceftazidime was unchanged when these drugs were given concurrently. The volume of distribution of tobramycin at steady state was increased by 20% in normal volunteers when given with ceftazidime. The increase in distribution was accompanied by a slight decrease in ceftazidime elimination rate. No additional alteration in dosing over those necessary to adjust for a decrease in renal function is necessary when giving this combination.
我们研究了在正常志愿者和无尿患者中，单独给予头孢他啶和妥布霉素以及联合给予这两种药物时它们在体内的相互作用。血浆浓度数据的动力学分析表明，同时给予这些药物时，它们的处置仅有轻微变化。然而，同时给予这些药物时，妥布霉素和头孢他啶的清除率并未改变。在正常志愿者中，与头孢他啶合用时，稳态下妥布霉素的分布容积增加了20%。分布容积的增加伴随着头孢他啶消除率的轻微下降。给予这种联合用药时，除了因肾功能下降而需要调整的剂量外，无需进行额外的剂量调整。
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