Division of Nephrology and Hypertension, Department of Medicine, S3223 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA.
J Am Soc Nephrol. 2011 Dec;22(12):2166-81. doi: 10.1681/ASN.2011080865. Epub 2011 Oct 27.
Pioneering investigations conducted over a half century ago on tonicity, transcapillary fluid exchange, and the distribution of water and solute serve as a foundation for understanding the physiology of body fluid spaces. With passage of time, however, some of these concepts have lost their connectivity to more contemporary information. Here we examine the physical forces determining the compartmentalization of body fluid and its movement across capillary and cell membrane barriers, drawing particular attention to the interstitium operating as a dynamic interface for water and solute distribution rather than as a static reservoir. Newer work now supports an evolving model of body fluid dynamics that integrates exchangeable Na(+) stores and transcapillary dynamics with advances in interstitial matrix biology.
半个多世纪以前开展的开创性研究涉及渗透压、跨毛细血管液体交换以及水和溶质的分布，这些研究为理解体液空间生理学奠定了基础。然而，随着时间的推移，其中一些概念已经与更现代的信息失去了联系。在这里，我们研究了决定体液分隔及其在毛细血管和细胞膜屏障中移动的物理力，特别关注间质作为水和溶质分布的动态界面而不是静态储库的作用。现在，新的研究工作支持体液动力学的一个不断发展的模型，该模型将可交换的 Na(+) 储存和跨毛细血管动力学与间质基质生物学的进步相结合。
