Department of Biochemistry, Faculty of Natural Sciences, Institute of Biological Sciences, University of Rostock, Albert-Einstein-Strasse 3, 18059 Rostock, Germany.
Arch Gynecol Obstet. 2012 Apr;285(4):1145-51. doi: 10.1007/s00404-011-2120-6. Epub 2011 Oct 30.
Phytoestrogens are plant-derived, non-steroidal phytochemicals with anticarcinogenic potential. The major structural classes are the isoflavones and lignans. The aim of this study was to compare the effect of the plant-derived lignans secoisolariciresinol and matairesinol with the human lignans enterodiol and enterolactone as well as with 17β estradiol and tamoxifen on cell proliferation of breast carcinoma cell lines.
The influence of the lignans, 17β estradiol and tamoxifen on cell proliferation was determined using the BrdU test in MCF 7 and BT 20 cell lines.
Enterodiol and enterolactone induced a stronger inhibition of cell growth in MCF 7 and BT 20 cells than secoisolariciresinol and matairesinol. The inhibition effects were less expressed in the BT 20 than in the MCF 7 cells.
The human lignans enterodiol and enterolactone are more biologically active than their precursors secoisolariciresinol and matairesinol, and may be defined as the real drugs in cancer prevention.
植物雌激素是具有抗癌潜力的植物源性、非甾体植物化学物质。主要的结构类别是异黄酮和木脂素。本研究的目的是比较植物源性木脂素开环异落叶松脂素和马尾松脂素与人体木脂素肠二醇和肠内酯以及 17β 雌二醇和他莫昔芬对乳腺癌细胞系细胞增殖的影响。
使用 BrdU 试验在 MCF 7 和 BT 20 细胞系中确定木脂素、17β 雌二醇和他莫昔芬对细胞增殖的影响。
肠二醇和肠内酯在 MCF 7 和 BT 20 细胞中诱导的细胞生长抑制作用强于开环异落叶松脂素和马尾松脂素。BT 20 细胞中的抑制作用比 MCF 7 细胞中的抑制作用弱。
人体木脂素肠二醇和肠内酯比其前体开环异落叶松脂素和马尾松脂素具有更强的生物活性，可被定义为癌症预防的真正药物。
