β-葡聚糖对免疫细胞的刺激作用。
Stimulatory Effect of β-glucans on Immune Cells.
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
出版信息
Immune Netw. 2011 Aug;11(4):191-5. doi: 10.4110/in.2011.11.4.191. Epub 2011 Aug 31.
Abstract
β-Glucans are naturally occurring polysaccharides that are produced by bacteria, yeast, fungi, and many plants. Although their pharmacological activities, such as immunomodulatory, anti-infective and anti-cancer effects, have been well studied, it is still unclear how β-glucans exert their activities. However, recent studies on the β-glucan receptors shed some light on their mechanism of action. Since β-glucans have large molecular weights, they must bind surface receptors to activate immune cells. In this review, we summarize the immunopharmacological activities and the potential receptors of β-glucans in immune cells.
摘要
β-葡聚糖是一种天然存在的多糖，由细菌、酵母、真菌和许多植物产生。尽管它们的药理活性，如免疫调节、抗感染和抗癌作用，已经得到了很好的研究，但β-葡聚糖如何发挥作用仍不清楚。然而，最近对β-葡聚糖受体的研究揭示了它们作用机制的一些线索。由于β-葡聚糖的分子量较大，它们必须与表面受体结合才能激活免疫细胞。在这篇综述中，我们总结了β-葡聚糖在免疫细胞中的免疫药理学活性和潜在受体。
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