Increnovo LLC, Whitefish Bay, WI 53217, USA.
Human Performance Lab, School of Exercise and Sport Science, University of Mary Hardin-Baylor, Belton, TX 76513, USA.
Nutrients. 2024 Mar 30;16(7):1012. doi: 10.3390/nu16071012.
Biotransformation of minerals via glycosylation by microorganisms such as yeast and/or probiotics yields nutrients bound to a food matrix, resulting in increased bioavailability. The purpose of this study was to compare the effects of glycoprotein matrix-bound zinc (GPM) on absorption compared to inorganic zinc oxide. Sixteen participants ingested 11 mg of zinc as either GPM™ Soy-Free Zinc (GPM, Ashland, Kearny, NJ, USA) or zinc oxide (USP). Blood samples were taken at 0 (i.e., baseline), 30, 60, 90, 120, 180, 240, 300, 360, 420, and 480 min post-ingestion. GPM zinc concentrations were significantly higher at 120 min ( = 0.02; 12.4 ± 5.1 mcg/dL), 180 min ( = 0.002; 16.8 ± 5.1 mcg/dL), and 240 min ( = 0.007; 14.6 ± 5.1 mcg/dL) in comparison to USP zinc oxide. In addition, GPM zinc significantly increased iAUC by 40% (5840 ± 2684 vs. 4183 ± 1132 mcg/dL * 480 min, = 0.02), and Cmax values were 10% higher in GPM compared to USP (148 ± 21 mcg/dL vs. 135 ± 17.5 mcg/dL, = 0.08). Tmax was 12% slower in GPM compared to USP (112.5 ± 38.7 min vs. 127.5 ± 43.1 min); however, differences in Tmax failed to reach statistical significance ( = 0.28). Zinc bound to a glycoprotein matrix significantly increased absorption compared to zinc oxide.
通过酵母和/或益生菌的糖化作用将矿物质生物转化为与食物基质结合的营养素，从而提高生物利用度。本研究旨在比较糖蛋白基质结合锌（GPM）与氧化锌在吸收方面的效果。16 名参与者摄入 11 毫克锌，分别来自 GPM™无大豆锌（GPM，美国新泽西州肯尼 Ashland）或氧化锌（USP）。在摄入后 0（即基线）、30、60、90、120、180、240、300、360、420 和 480 分钟时采集血样。与 USP 氧化锌相比，GPM 锌在 120 分钟（ = 0.02；12.4 ± 5.1 mcg/dL）、180 分钟（ = 0.002；16.8 ± 5.1 mcg/dL）和 240 分钟（ = 0.007；14.6 ± 5.1 mcg/dL）时的浓度明显更高。此外，GPM 锌使 iAUC 显著增加 40%（5840 ± 2684 与 4183 ± 1132 mcg/dL * 480 min， = 0.02），并且 GPM 中的 Cmax 值比 USP 高 10%（148 ± 21 mcg/dL 与 135 ± 17.5 mcg/dL， = 0.08）。与 USP 相比，GPM 的 Tmax 慢 12%（112.5 ± 38.7 分钟与 127.5 ± 43.1 分钟； = 0.28）；然而，Tmax 的差异未达到统计学意义。与氧化锌相比，与糖蛋白基质结合的锌显著增加了吸收。
