Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan.
Chem Commun (Camb). 2011 Dec 21;47(47):12661-3. doi: 10.1039/c1cc15662d. Epub 2011 Oct 31.
Continuous in situ generation of phosgene and its use in acid chloride formation in a microflow system were demonstrated. The acid chloride was subsequently coupled with an amine in high yield without severe epimerization.
连续原位生成光气及其在微流系统中用于酰氯的形成得到了证实。随后，酰氯与胺以高产率偶联，而没有严重的差向异构化。
