Animal Health Division, AgResearch New Zealand Limited, Palmerston North, New Zealand.
Parasite Immunol. 2012 Jan;34(1):40-4. doi: 10.1111/j.1365-3024.2011.01341.x.
Although immunity to Echinococcus granulosus in sheep has been shown to be antibody-mediated and complement-dependent and can be passively transferred in colostrum, in animals vaccinated with EG95, the relationship between protection against an oral challenge infection with E. granulosus eggs and anti-EG95 IgG ELISA absorbance values at the time of challenge has not been satisfactorily proven. Using a combination of results from three EG95 vaccination trials, we have found that the IgG ELISA absorbance at the time of challenge infection explains approximately 50% (P ≤ 0·001) of the variability in the percentage protection against an oral challenge with E. granulosus eggs (transformed with arcsin).
尽管已经证明绵羊对细粒棘球蚴的免疫力是抗体介导和补体依赖的，并可以在初乳中被动转移，但在接种 EG95 的动物中，针对棘球蚴卵口服感染的保护与 EG95 IgG ELISA 吸光度值在挑战时之间的关系尚未得到令人满意的证明。使用来自三项 EG95 疫苗接种试验的结果组合，我们发现，在挑战感染时的 IgG ELISA 吸光度值解释了大约 50%（P ≤ 0·001）的口服棘球蚴卵挑战的保护百分比的变异性（用反正弦转换）。
