Gädicke Paula, Heath David, Medina-Brunet Angela, Siva-de la Fuente María Carolina, Espinoza-Rojas Hellen, Villaguala-Pacheco Carmen, Rubilar Makarena, Cerda Carolina, Quezada Manuel, Rojas Daniela, Henríquez AnaLía, Loyola Marco, Landaeta-Aqueveque Carlos
Facultad de Ciencias Veterinarias, Universidad de Concepción, Vicente Méndez 595, Chillán 3812120, Chile.
Wallaceville Animal Research Centre, AgResearch, P.O. Box 40063, Upper Hutt 6007, New Zealand.
Animals (Basel). 2022 Mar 8;12(6):679. doi: 10.3390/ani12060679.
Echinococcosis is a neglected zoonosis that uses dogs and sheep as its main hosts in Chile. The Eg95 vaccine against sheep infection has been included in some control programs. Here, we assess the efficacy of the vaccination program in the hyperendemic Alto Biobío commune after 3 years of execution. Fisher’s test and generalized linear models were used in the assessment. The program tried to offer a first dose at 2 months of age, a booster 1 month later, and yearly vaccination. Given logistic difficulties, important delays in vaccination occurred, and most animals did not receive the first booster. Dog deworming was not included in the program. Likely due to the aforementioned factors, the overall frequency of infection was not lower, but the proportion of large (>5 mm) cysts and fertile cysts was smaller after the program. The frequency of infection and/or the number of cysts were lower when the age at first dose was younger and the first booster was administered 1 month after the first dose. The results suggest that vaccination affects both cyst development after the larvae reach the target organs, as well as the development of the protoscolex once the cysts start developing.
棘球蚴病是一种被忽视的人畜共患病，在智利，狗和羊是其主要宿主。针对绵羊感染的Eg95疫苗已被纳入一些防控计划。在此，我们评估了在高度流行的比奥比奥省上区实施3年后的疫苗接种计划的效果。评估中使用了费舍尔检验和广义线性模型。该计划试图在动物2月龄时提供首剂疫苗，1个月后进行加强免疫，并每年接种。由于后勤方面的困难，疫苗接种出现了严重延误，大多数动物没有接受首次加强免疫。该计划未包括对狗进行驱虫。可能由于上述因素，总体感染率并未降低，但计划实施后，大囊肿（>5毫米）和有活力囊肿的比例较小。首剂接种年龄越小且在首剂接种1个月后进行首次加强免疫时，感染率和/或囊肿数量较低。结果表明，疫苗接种既影响幼虫到达靶器官后囊肿的发育，也影响囊肿开始发育后原头节的发育。
