Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reprod Biol Endocrinol. 2011 Nov 1;9:144. doi: 10.1186/1477-7827-9-144.
There is no clear and contemporaneous method for screening of idiopathic hirsutism (IH) and polycystic ovary syndrome (PCOS) at the community level and current estimates regarding their prevalence are limited. We aimed to ascertain the prevalence of IH and PCOS in a randomly selected sample of reproductive aged female participants of the Tehran Lipid and Glucose Study (TLGS).
One thousand and two women, aged 18-45 years, were randomly selected from among reproductive aged women who participated in the TLGS. Those women with either hirsutism or menstrual dysfunction were assessed for biochemical hyperandrogenemia; whereas those participants with hirsutism per se were further assessed for subclinical menstrual dysfunction. PCOS were diagnosed using the National Institute of Health (NIH) criteria. IH was defined as hirsutism without clinical or sub clinical menstrual dysfunction or biochemical hyperandrogenemia (BH).
The mean±SD of age of study population was 29.2±8.7 years. Estimated prevalences of idiopathic hirsutism and pure menstrual dysfunction were 13.0% (95% CI: 10.9%-15.1%) and 1.5%(95% CI: 1.1%-1.9%), respectively. The prevalence of PCOS was 8.5% (95% CI: 6.8%-10.2%); more than one third of these cases would possibly have remained undiagnosed or misdiagnosed, had we not assessed them for subclinical menstrual dysfunction or biochemical hyperandrogenemia.
These data from a large representative and non selected population of women confirm the concept that IH and PCOS are the two most common gynecological endocrinopathies among reproductive aged women. The estimated prevalence of these conditions is highly influenced by their screening methods at the community level.
目前，在社区层面上，尚无明确且同时适用于特发性多毛症（IH）和多囊卵巢综合征（PCOS）的筛查方法，且目前对其患病率的估计有限。我们旨在确定随机选择的德黑兰血脂和血糖研究（TLGS）中育龄女性参与者中 IH 和 PCOS 的患病率。
从参加 TLGS 的育龄妇女中随机选择 1020 名年龄在 18-45 岁之间的妇女。对那些患有多毛症或月经功能障碍的妇女进行生化高雄激素血症评估；而那些单纯患有多毛症的参与者则进一步进行亚临床月经功能障碍评估。使用美国国立卫生研究院（NIH）标准诊断 PCOS。IH 定义为无临床或亚临床月经功能障碍或生化高雄激素血症（BH）的多毛症。
研究人群的平均年龄为 29.2±8.7 岁。特发性多毛症和单纯月经功能障碍的估计患病率分别为 13.0%（95%CI：10.9%-15.1%）和 1.5%（95%CI：1.1%-1.9%）。PCOS 的患病率为 8.5%（95%CI：6.8%-10.2%）；如果我们不评估亚临床月经功能障碍或生化高雄激素血症，那么这些病例中有超过三分之一可能未被诊断或误诊。
这些来自大型代表性和非选择性育龄妇女人群的数据证实了 IH 和 PCOS 是育龄妇女中最常见的妇科内分泌疾病的概念。这些疾病的估计患病率受到社区层面筛查方法的高度影响。
