Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt.
Int J Gynaecol Obstet. 2010 Jun;109(3):239-41. doi: 10.1016/j.ijgo.2010.01.014. Epub 2010 Mar 2.
To investigate the association of insulin resistance with dyslipidemia and metabolic syndrome (MBS) in women with polycystic ovary syndrome (PCOS).
Fasting glucose (G), insulin (I), and lipid levels were measured in 50 infertile women with PCOS. A fasting G/I ratio of 4.5 or less (n=29) defined insulin resistance (IR).
The mean levels of total cholesterol (P<0.001), low-density lipoprotein (P=0.02), and triglycerides (P<0.001) were significantly higher and the mean levels of high-density lipoprotein were significantly lower (P<0.001) in the IR group. The prevalence of MBS (P=0.02) and obesity (P=0.04), hypertension (P=0.02), fasting hyperglycemia (P=0.03), low high-density lipoprotein levels (P=0.02), and hypertriglyceridemia (P=0.02) were also significantly higher in the IR group.
Insulin resistance is associated with dyslipidemia and MBS in women with PCOS. Lifestyle modification and insulin-sensitizing agents should be part of the management plan.
探讨多囊卵巢综合征（PCOS）妇女胰岛素抵抗与血脂异常及代谢综合征（MBS）的关系。
测量 50 例不孕 PCOS 妇女的空腹血糖（G）、胰岛素（I）和血脂水平。空腹 G/I 比值为 4.5 或更低（n=29）定义为胰岛素抵抗（IR）。
IR 组总胆固醇（P<0.001）、低密度脂蛋白（P=0.02）和甘油三酯（P<0.001）水平显著升高，高密度脂蛋白水平显著降低（P<0.001）。IR 组 MBS（P=0.02）、肥胖（P=0.04）、高血压（P=0.02）、空腹高血糖（P=0.03）、低高密度脂蛋白水平（P=0.02）和高甘油三酯血症（P=0.02）的患病率也显著升高。
胰岛素抵抗与 PCOS 妇女的血脂异常和 MBS 有关。生活方式的改变和胰岛素增敏剂应作为管理计划的一部分。
