Verrell P A, McCabe N R
Department of Ecology and Evolution, University of Chicago, IL 60637.
Med Hypotheses. 1990 Jul;32(3):235-8. doi: 10.1016/0306-9877(90)90129-3.
Maternal-fetal histocompatibility as a consequence of sharing of MHC antigens between males and females may result in an increased incidence of spontaneous abortion. We propose that such a response may be of evolutionary significance in inbred populations where partners that are similar at MHC loci also are likely to share deleterious recessive alleles due to common descent. In this scenario, spontaneous abortion is regarded as an adaptive response on behalf of the mother, who terminates at an early stage her investment in an offspring which would likely be of low reproductive value if carried to term.
由于男性和女性之间MHC抗原的共享导致的母婴组织相容性可能会增加自然流产的发生率。我们提出，这种反应在近亲繁殖群体中可能具有进化意义，在这种群体中，MHC基因座相似的伴侣也可能由于共同的血统而共享有害的隐性等位基因。在这种情况下，自然流产被视为母亲的一种适应性反应，母亲会在早期终止对一个如果足月出生可能生殖价值较低的后代的投入。
