Schacter B, Muir A, Gyves M, Tasin M
Lancet. 1979 Apr 14;1(8120):796-9. doi: 10.1016/s0140-6736(79)91317-5.
To test the contribution of a putative human analogue of the murine T locus to neural-tube defects (N.T.D.) and involuntary fetal wastage, HLA-A, B compatibility between husband and wife was studied in a group of 77 couples with known obstetric histories. The frequency of sharing of HLA-A,B antigens was significantly higher in 13 couples with recurrent fetal loss at one gestational age and in 11 couples whose offspring had had a lethal N.T.D. than in 17 couples with three or more normal pregnancies. The extent of HLA compatibility--that is, the number of antigens shared by husbands and wives--was significantly higher in 16 couples with one spontaneous abortion, 23 couples with recurrent spontaneous abortions, and 21 couples with N.T.D. offspring than in controls. These data are consistent with a contribution of a locus in or near the HLA complex to N.T.D. and involuntary fetal wastage.
为了检测假定的小鼠T位点的人类类似物对神经管缺陷（NTD）和自然流产的影响，在一组77对有已知产科病史的夫妇中研究了夫妻之间的HLA - A、B相容性。在13对在一个孕龄期有反复胎儿丢失的夫妇以及11对其后代患有致死性NTD的夫妇中，HLA - A、B抗原共享频率显著高于17对有三次或更多次正常妊娠的夫妇。在16对有一次自然流产、23对有反复自然流产以及21对有NTD后代的夫妇中，HLA相容性程度（即夫妻共享的抗原数量）显著高于对照组。这些数据与HLA复合体中或其附近的一个位点对NTD和自然流产有影响这一观点一致。
