Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Neurobiol Aging. 2012 May;33(5):1006.e25-36. doi: 10.1016/j.neurobiolaging.2011.10.001. Epub 2011 Nov 1.
The present study evaluated cerebrovascular disease (CVD), β-amyloid (Aβ), and cognition in clinically normal elderly adults. Fifty-four participants underwent magnetic resonance imaging (MRI), Pittsburgh compound B (PIB)-positron emission tomography (PET) imaging, and neuropsychological evaluation. High white matter hyperintensity burden and/or presence of infarct defined CVD status (CVD-: n = 27; CVD+: n = 27). PIB-positron emission tomography ratios of Aβ deposition were extracted using Logan plotting (cerebellar reference). Presence of high levels of Aβ in prespecified regions determined PIB status (PIB-: n = 33; PIB+: n = 21). Executive functioning and episodic memory were measured using composite scales. CVD and Aβ, defined as dichotomous or continuous variables, were unrelated to one another. CVD+ participants showed lower executive functioning (p = 0.001) when compared with CVD- individuals. Neither PIB status nor amount of Aβ affected cognition (ps ≥ 0.45), and there was no statistical interaction between CVD and PIB on either cognitive measure. Within this spectrum of normal aging CVD and Aβ aggregation appear to be independent processes with CVD primarily affecting cognition.
本研究评估了脑血管疾病（CVD）、β-淀粉样蛋白（Aβ）和认知功能在临床正常的老年人群中的情况。54 名参与者接受了磁共振成像（MRI）、匹兹堡化合物 B（PIB）正电子发射断层扫描（PET）成像和神经心理学评估。高脑白质高信号负担和/或存在梗死定义了 CVD 状态（CVD-：n=27；CVD+：n=27）。使用 Logan 绘图（小脑参考）提取 Aβ沉积的 PIB-PET 比值。在预定区域存在高水平的 Aβ决定了 PIB 状态（PIB-：n=33；PIB+：n=21）。使用复合量表测量执行功能和情景记忆。CVD 和 Aβ，定义为二分类或连续变量，彼此之间没有相关性。与 CVD-个体相比，CVD+参与者的执行功能较低（p=0.001）。PIB 状态或 Aβ 量均不影响认知（p≥0.45），并且在这两个认知测量指标上，CVD 和 PIB 之间没有统计学交互作用。在正常衰老的范围内，CVD 和 Aβ 聚集似乎是独立的过程，CVD 主要影响认知。
