通过钯催化 N-甲氧基苯甲酰胺的 C-H 活化合成异吲哚啉酮。
Synthesis of isoindolinones via palladium-catalyzed C-H activation of N-methoxybenzamides.
机构信息
Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
出版信息
Chem Commun (Camb). 2011 Dec 28;47(48):12789-91. doi: 10.1039/c1cc15897j. Epub 2011 Nov 3.
PMID:22048147
Abstract
The synthesis of isoindolinones from N-methoxybenzamides and alkenes has been achieved by Pd-catalyzed ortho sp(2) C-H activation and intramolecular oxidative amidation, which involve the cleavage of four bonds and formation of two bonds.
摘要
通过钯催化的邻 sp(2) C-H 活化和分子内氧化酰胺化，实现了 N-甲氧基苯甲酰胺和烯烃合成异吲哚啉酮，其中涉及到四个键的断裂和两个键的形成。
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